Cobo F, García C, Talavera P, Bravo J, Cabrera C, Concha A
Infectious Pathology Unit (Dept. of Pathology), Hospital Universitario Virgen de las Nieves, Avenida Fuerzas Armadas 2, 18014 Granada, Spain.
Infection. 2006 Jun;34(3):176-80. doi: 10.1007/s15010-006-5026-7.
The papillary squamous cell carcinoma (PSCC) is a rare variant of the head and neck squamous cell carcinoma. Established etiological factors can include tobacco smoking and heavy alcohol abuse. Moreover, human papillomavirus infection can be involved in the pathogenesis of PSCC. This tumor is more frequent in patients with immunosuppression including those who have received a transplant. Most of the cases are produced by genotype HPV-6 and HPV-16, although there is a possibility of infection by other HPV subtypes. We present a case report of a PSCC and papilloma with oropharyngeal location in which high-risk HPV type 16 and low-risk HPV type 6, respectively, were identified by PCR in a renal transplant patient.
乳头状鳞状细胞癌（PSCC）是头颈部鳞状细胞癌的一种罕见变体。已确定的病因包括吸烟和大量酗酒。此外，人乳头瘤病毒感染可能参与PSCC的发病机制。这种肿瘤在免疫抑制患者中更常见，包括接受过移植的患者。大多数病例由HPV - 6和HPV - 16基因型引起，不过也有可能感染其他HPV亚型。我们报告一例口咽部位的PSCC和乳头状瘤病例，在一名肾移植患者中通过PCR分别鉴定出高危型HPV 16和低危型HPV 6。
