Atarbashi-Moghadam Saede, Lotfi Ali, Roghanizadeh Leyla, Mirebeigi Jamasbi Seyed Sepehr, Akbarzadeh Fathabadi Zeinab
Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Researcher, Iranian Center for Endodontic Research, Research Institute for Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
J Dent (Shiraz). 2025 Jun 1;26(2):186-193. doi: 10.30476/dentjods.2025.103223.2435. eCollection 2025 Jun.
Squamous cell carcinoma (SCC) is the most common oral malignancy. Conventional types are classified as well-, moderately- and poorly differentiated, which are usually easy to diagnose microscopically. Still, uncommon variants such as basaloid, verrucous, spindle cell, papillary, adenosquamous, acantholytic, cuniculatum, clear cell, and pigmented SCC make a diagnostic challenge for pathologists. This report presents four rare cases of oral SCC with histopathologic diagnosis of spindle cell carcinoma, carcinoma cuniculatum, papillary SCC, and basaloid SCC focusing on microscopic characteristics and differential diagnosis. The apprehensive knowledge about the unique histopathologic features of these uncommon variants is crucial to avoid their misdiagnoses and provide appropriate treatment.
鳞状细胞癌（SCC）是最常见的口腔恶性肿瘤。传统类型分为高分化、中分化和低分化，通常在显微镜下易于诊断。然而，一些罕见的变体，如基底样、疣状、梭形细胞、乳头状、腺鳞、棘层松解性、漏斗状、透明细胞和色素性SCC，给病理学家带来了诊断挑战。本报告介绍了4例罕见的口腔SCC病例，其组织病理学诊断分别为梭形细胞癌、漏斗状癌、乳头状SCC和基底样SCC，重点关注显微镜特征和鉴别诊断。了解这些罕见变体独特的组织病理学特征对于避免误诊和提供适当治疗至关重要。
