钯催化末端炔烃与铬(0)费歇尔碳烯配合物的交叉偶联反应。
Pd-Catalyzed Cross-Coupling of Terminal Alkynes with Chromium(0) Fischer Carbene Complexes.
机构信息
Beijing National Laboratory of Molecular Sciences (BNLMS) and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University , Beijing 100871, China.
State Key Laboratory of Organometallic Chemistry, Chinese Academy of Sciences , Shanghai 200032, China.
出版信息
Org Lett. 2017 Jun 2;19(11):2861-2864. doi: 10.1021/acs.orglett.7b01096. Epub 2017 May 22.
Alkyl chromium(0) carbene complexes typically undergo cycloadditions with alkynes to afford carbo- or heterocyclic compounds. In the presence of Pd catalyst, it is demonstrated that a traditional cycloaddition pathway is completely altered: instead of cycloaddition, oxidative cross-coupling reaction of alkyl chromium(0) carbene complexes with terminal alkynes occurs. The coupling reaction exhibits excellent functional group tolerance and good efficiency.
烷基铬(0)卡宾配合物通常与炔烃发生环加成反应，生成碳环或杂环化合物。在钯催化剂的存在下，研究表明传统的环加成途径完全改变：烷基铬(0)卡宾配合物与末端炔烃发生氧化交叉偶联反应，而不是环加成反应。该偶联反应具有良好的官能团容忍性和较高的效率。
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