Rockwell Enid, Jackson Edward, Vilke Gary, Jeste Dilip V
Departments of Psychiatry, Neurosciences, and Internal Medicine, University of California School of Medicine, and Veterans Affairs Medical Center, La Jolla, CA.
Am J Geriatr Psychiatry. 1994;2(2):157-164. doi: 10.1097/00019442-199405000-00009. Epub 2013 Jan 28.
The authors analyzed data on delusions and associated neuropsychiatric symptoms in 1,229 consecutive patients with Alzheimer's disease (AD) at nine university-based State of California Alzheimer's Disease Diagnostic and Treatment Centers. Thirty-four percent of these patients had delusions. The delusional patients were older, more likely to be female, and had a later onset of AD than the nondelusional group. Compared to the nondelusional patients, the delusional patients also had more severe global cognitive impairment, along with a higher prevalence of hallucinations, agitation, depression, and gait disturbance, as well as family and marital difficulties and self-care problems.
作者分析了加利福尼亚州九家大学附属阿尔茨海默病诊断与治疗中心的1229例连续性阿尔茨海默病（AD）患者的妄想及相关神经精神症状数据。这些患者中34%有妄想症状。与无妄想组相比，有妄想症状的患者年龄更大，女性更多，AD发病更晚。与无妄想患者相比，有妄想症状的患者还存在更严重的整体认知障碍，同时幻觉、激越、抑郁、步态障碍的患病率更高，以及存在家庭、婚姻问题和自我照料困难。
