纳米粒子比标准形式的氧化锌更能增强酮洛芬在大鼠体内的抗炎活性。

Beneficial effect of nanoparticles over standard form of zinc oxide in enhancing the anti-inflammatory activity of ketoprofen in rats.

机构信息

Department of Radioligands, Faculty of Pharmacy, Jagiellonian University Medical College, Kraków, Poland.

出版信息

Pharmacol Rep. 2017 Aug;69(4):679-682. doi: 10.1016/j.pharep.2017.02.004. Epub 2017 Feb 9.

DOI:10.1016/j.pharep.2017.02.004

PMID:28531763

Abstract

BACKGROUND

Zinc is known as an anti-inflammatory agent. Recent studies demonstrated the usage of zinc ions for enhancing the anti-inflammatory effect of Non-Steroidal Anti-inflammatory Drugs (NSAIDs).

METHODS

This study compares the influence of chronic administration of zinc oxide nanoparticles (ZnO-NPs) and zinc oxide standard form (ZnO-S) on the anti-inflammatory and gastric activity of ketoprofen in rats. Both ZnO-S and ZnO-NPs were administered at doses of 7 or 14mg/kg (intraperitoneally (ip) and per os (po)) for 2 weeks followed by single po ketoprofen administration (in three doses: 5, 10, and 20mg/kg).

RESULTS

The ZnO-NPs (but not ZnO-S) at a dose of 14mg/kg ip reduced the carrageenan-induced paw edema at the second hour after carrageenan administration and enhanced the ketoprofen anti-inflammatory activity at second and third hour after carrageenan administration. A dose of 7mg/kg of both forms administered ip was ineffective in these measures. ZnO-NPs and ZnO-S administered po did not affect the carrageenan-induced paw edema or ketoprofen anti-inflammatory activity. ZnO-S and ZnO-NPs administered po and ip at both doses (7 and 14mg/kg) protected the gastric mucosa from ketoprofen-induced gastric ulcer.

CONCLUSION

Zinc oxide nanoparticles demonstrated beneficial effects over standard form in enhancing the anti-inflammatory activity of ketoprofen.

摘要

背景

锌被认为是一种抗炎剂。最近的研究表明，锌离子可用于增强非甾体抗炎药（NSAIDs）的抗炎作用。

方法

本研究比较了慢性给予氧化锌纳米粒子（ZnO-NPs）和氧化锌标准形式（ZnO-S）对大鼠酮洛芬抗炎和胃活性的影响。ZnO-S 和 ZnO-NPs 分别以 7 或 14mg/kg 的剂量（腹膜内（ip）和口服（po））给药 2 周，然后单次 po 给予酮洛芬（三种剂量：5、10 和 20mg/kg）。

结果

ZnO-NPs（而不是 ZnO-S）以 14mg/kg ip 给药可降低角叉菜胶诱导的爪肿胀，在角叉菜胶给药后第 2 小时，并增强角叉菜胶给药后第 2 和第 3 小时的酮洛芬抗炎活性。两种形式的 7mg/kg ip 剂量在这些措施中均无效。po 给予 ZnO-NPs 和 ZnO-S 均不影响角叉菜胶诱导的爪肿胀或酮洛芬抗炎活性。po 和 ip 给予两种剂量（7 和 14mg/kg）的 ZnO-S 和 ZnO-NPs 均可保护胃粘膜免受酮洛芬引起的胃溃疡。