Department of Pharmaceutical Technology, Faculty of Pharmacy, Gazi University, 06330 Etiler, Ankara, Turkey.
Curr Drug Deliv. 2013 Feb;10(1):32-8. doi: 10.2174/1567201811310010006.
Recently ZnO quantum dots are reported to be very promising for drug delivery. It has also been reported that adsorptive material can deliver drug molecules by simple adsorption and they release the drug at site of action by subsequent desorption. This has been shown for carbon nanotubes and some other hydrophobic molecules for transdermal applications in the literature. Therefore it was aimed to find the effect of ZnO quantum dots on transdermal penetrations of selected model drug molecules (ketoprofen and dexketoperofen). Drug coated ZnO quantum dots were found to increase transdermal penetration of ketoprofen and dexketoprofen through rat skin.
最近,氧化锌量子点被报道在药物输送方面非常有前途。也有报道称,吸附材料可以通过简单的吸附来输送药物分子,然后通过随后的解吸在作用部位释放药物。这在文献中已经在碳纳米管和一些其他疏水分子用于经皮应用中得到了证明。因此,目的是研究氧化锌量子点对选定模型药物分子(酮洛芬和右旋酮洛芬)经皮渗透的影响。研究发现,涂有药物的氧化锌量子点增加了酮洛芬和右旋酮洛芬通过大鼠皮肤的经皮渗透。