Li Haipeng, Song Xiaoqing, Li Baoe, Kang Jianli, Liang Chunyong, Wang Hongshui, Yu Zhenyang, Qiao Zhijun
School of Materials Science and Engineering, Hebei University of Technology, Tianjin 300130, China.
State Key Laboratory of Hollow Fiber Membrane Materials and Processes, Tianjin Polytechnic University, Tianjin 300387, China; School of Materials Science and Engineering, Tianjin Polytechnic University, Tianjin 300387, China.
Mater Sci Eng C Mater Biol Appl. 2017 Aug 1;77:1078-1087. doi: 10.1016/j.msec.2017.04.048. Epub 2017 Apr 7.
Carbon nanotube (CNT)-reinforced mesoporous hydroxyapatite (HA) composites with excellent mechanical and biological properties were fabricated successfully by the in situ chemical deposition of mesoporous HA on homogeneously dispersed CNTs. The CNTs are first synthesized in situ on HA nanopowders by chemical vapor deposition, and then, the HA particles with mesoporous structures are deposited in situ onto the as-grown CNTs by using cetyl trimethyl ammonium bromide as templates to form mesoporous HA encapsulated CNTs (CNT@meso-HA). The modification of CNTs by mesoporous HA leads to strong CNT-HA interfacial bonding, resulting in efficient load transfer between CNT and HA and improved mechanical properties of CNT/HA composites. More importantly, the mesoporous HA structure has a high specific surface area and large surface roughness that greatly promote the cell adhesion and proliferation, resulting in better biocompatibility and improved osteoblast viability (MC3T3-E1) compared to those fabricated by traditional methods. Therefore, the obtained CNT@meso-HA composites are expected to be promising materials for bone regeneration and implantation applications.
通过在均匀分散的碳纳米管（CNT）上原位化学沉积介孔羟基磷灰石（HA），成功制备了具有优异机械性能和生物学性能的碳纳米管增强介孔羟基磷灰石复合材料。首先通过化学气相沉积法在HA纳米粉末上原位合成碳纳米管，然后以十六烷基三甲基溴化铵为模板，将具有介孔结构的HA颗粒原位沉积到生长好的碳纳米管上，形成介孔HA包裹的碳纳米管（CNT@meso-HA）。介孔HA对碳纳米管的改性导致了碳纳米管与HA之间强烈的界面结合，从而实现了碳纳米管与HA之间有效的载荷传递，并改善了CNT/HA复合材料的机械性能。更重要的是，介孔HA结构具有高比表面积和大表面粗糙度，极大地促进了细胞的黏附和增殖，与传统方法制备的材料相比，具有更好的生物相容性和更高的成骨细胞活力（MC3T3-E1）。因此，所获得的CNT@meso-HA复合材料有望成为骨再生和植入应用的有前途的材料。
