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钛基底上溶胶-凝胶法制备的羟基磷灰石-碳纳米管/二氧化钛涂层

Sol-gel-derived hydroxyapatite-carbon nanotube/titania coatings on titanium substrates.

作者信息

Ji Xiaoli, Lou Weiwei, Wang Qi, Ma Jianfeng, Xu Haihong, Bai Qing, Liu Chuantong, Liu Jinsong

机构信息

Department of Prosthodontics, School and Hospital of Stomatology, Wenzhou Medical College, Wenzhou 325027, China.

State Key Laboratory of Oral Diseases, West China Stomatology Hospital, Sichuan University, Chengdu 610041, China.

出版信息

Int J Mol Sci. 2012;13(4):5242-5253. doi: 10.3390/ijms13045242. Epub 2012 Apr 24.

DOI:10.3390/ijms13045242
PMID:22606041
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3344277/
Abstract

In this paper, hydroxyapatite-carbon nanotube/titania (HA-CNT/TiO(2)) double layer coatings were successfully developed on titanium (Ti) substrates intended for biomedical applications. A TiO(2) coating was firstly developed by anodization to improve bonding between HA and Ti, and then the layer of HA and CNTs was coated on the surface by the sol-gel process to improve the biocompatibility and mechanical properties of Ti. The surfaces of double layer coatings were uniform and crack-free with a thickness of about 7 μm. The bonding strength of the HA-CNT/TiO(2) coating was higher than that of the pure HA and HA-CNT coatings. Additionally, in vitro cell experiments showed that CNTs promoted the adhesion of preosteoblasts on the HA-CNT/TiO(2) double layer coatings. These unique surfaces combined with the osteoconductive properties of HA exhibited the excellent mechanical properties of CNTs. Therefore, the developed HA-CNT/TiO(2) coatings on Ti substrates might be a promising material for bone replacement.

摘要

在本文中，成功地在用于生物医学应用的钛（Ti）基底上制备了羟基磷灰石-碳纳米管/二氧化钛（HA-CNT/TiO₂）双层涂层。首先通过阳极氧化制备TiO₂涂层以改善HA与Ti之间的结合，然后通过溶胶-凝胶法在表面涂覆HA和CNT层以改善Ti的生物相容性和机械性能。双层涂层表面均匀且无裂纹，厚度约为7μm。HA-CNT/TiO₂涂层的结合强度高于纯HA和HA-CNT涂层。此外，体外细胞实验表明，CNTs促进了前成骨细胞在HA-CNT/TiO₂双层涂层上的粘附。这些独特的表面与HA的骨传导特性相结合，展现出CNTs优异的机械性能。因此，在Ti基底上制备的HA-CNT/TiO₂涂层可能是一种有前途的骨替代材料。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ae3/3344277/591cca967d54/ijms-13-05242f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ae3/3344277/9cbd836639fa/ijms-13-05242f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ae3/3344277/7890faf8e590/ijms-13-05242f2a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ae3/3344277/d3dfb4a0f277/ijms-13-05242f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ae3/3344277/9ea52f97a1db/ijms-13-05242f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ae3/3344277/ac718d4bffa0/ijms-13-05242f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ae3/3344277/617aaf0605ce/ijms-13-05242f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ae3/3344277/70e6f115a44b/ijms-13-05242f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ae3/3344277/a8723f85dc09/ijms-13-05242f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ae3/3344277/591cca967d54/ijms-13-05242f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ae3/3344277/9cbd836639fa/ijms-13-05242f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ae3/3344277/7890faf8e590/ijms-13-05242f2a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ae3/3344277/d3dfb4a0f277/ijms-13-05242f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ae3/3344277/9ea52f97a1db/ijms-13-05242f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ae3/3344277/ac718d4bffa0/ijms-13-05242f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ae3/3344277/617aaf0605ce/ijms-13-05242f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ae3/3344277/70e6f115a44b/ijms-13-05242f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ae3/3344277/a8723f85dc09/ijms-13-05242f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ae3/3344277/591cca967d54/ijms-13-05242f9.jpg

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