Zolfizadeh Fatemeh, Ghorbani Maryam, Soltani Maryam, Rezaeian Shahab, Rajabi Abdolhalim, Etemad Koorosh, Hajipour Mahmoud, Ghasemi Ali, Yaghoobi Halimeh
Mother and Child Welfare Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Department of Epidemiology and Biostatistics, School of Public Health, Zahedan University of Medical Sciences, Zahedan, Iran.
Iran J Public Health. 2022 May;51(5):1118-1124. doi: 10.18502/ijph.v51i5.9411.
Congenital anomalies are one of the major public health problems and one of the leading cause of infant mortality and morbidity. We aimed to investigate some factors associated with infant mortality due to congenital anomalies in several provinces of Iran.
This case-control study was conducted on 2199 women referring health centers of nine provinces of Iran 2015-2018. Cases were defined as mothers with infant death due to congenital anomalies, and control group comprised of mothers with live birth or infant deaths due to other causes (n=1986). The descriptive data were expressed as percentage and frequency. Factors associated with infant death due to congenital anomalies were evaluated and analyzed at 95% confidence level by logistic regression analysis.
The multiple logistic regression analysis reveal that history of cesarean delivery [OR:2.13 ;95%CI (1.58-2.87)], maternal age [OR:1.94 ;95%CI (1.31-2.86)])], area of living [OR: 1.69;95%CI (1.22-2.33)], maternal smoking during pregnancy [OR: 1.41; 95%CI (1.02-1.95)], consanguineous marriage [OR:1.53;95%CI (1.12-2.08)], also low birth weight [OR: 3.09; 95%CI (2.23-4.30)] were significantly associated with infant death due to congenital anomalies.
Identification of factors associated with congenital anomalies has been shown to reduce treatment costs and medical complications of neonates. Therefore, genetic counseling and educational programs for high-risk women, and prenatal screening are essential to identify and prevent factors contributing to congenital abnormalities.
先天性异常是主要的公共卫生问题之一，也是婴儿死亡和发病的主要原因之一。我们旨在调查伊朗几个省份中与先天性异常导致的婴儿死亡相关的一些因素。
本病例对照研究于2015 - 2018年对伊朗九个省份健康中心的2199名妇女进行。病例定义为婴儿因先天性异常死亡的母亲，对照组由活产母亲或婴儿因其他原因死亡的母亲组成（n = 1986）。描述性数据以百分比和频率表示。通过逻辑回归分析在95%置信水平下评估和分析与先天性异常导致的婴儿死亡相关的因素。
多元逻辑回归分析显示，剖宫产史[比值比（OR）：2.13；95%置信区间（CI）（1.58 - 2.87）]、母亲年龄[OR：1.94；95%CI（1.31 - 2.86）]、居住地区[OR：1.69；95%CI（1.22 - 2.33）]、孕期母亲吸烟[OR：1.41；95%CI（1.02 - 1.95）]、近亲结婚[OR：1.53；95%CI（1.12 - 2.08）]以及低出生体重[OR：3.09；95%CI（2.23 - 4.30）]与先天性异常导致的婴儿死亡显著相关。
已证明识别与先天性异常相关的因素可降低新生儿的治疗成本和医疗并发症。因此，为高危妇女提供遗传咨询和教育项目以及产前筛查对于识别和预防导致先天性异常的因素至关重要。
