甲苯二异氰酸酯（TDI）哮喘中血清因子释放诱导的中性粒细胞趋化性增加。

Increased neutrophil leukocyte chemotaxis induced by release of a serum factor in toluene-diisocyanate (TDI) asthma.

作者信息

Valentino M, Governa M, Fiorini R

机构信息

Institute of Occupational Medicine, University of Ancona, Hospital Torrette, Italy.

出版信息

Lung. 1988;166(6):317-25. doi: 10.1007/BF02714064.

DOI:10.1007/BF02714064

PMID:2853258

Abstract

The activation of blood neutrophil leukocytes has been proven in subjects with IgE-mediated and non-IgE-mediated asthma. This event appears to be modulated by the release of humoral factors. We submitted 12 toluene-diisocyanate (TDI) asthmatic workers to TDI provocation. During the late asthmatic reaction there was release of a serum chemoattracting factor for normal neutrophil leukocytes and activation of asthmatic neutrophil leukocytes. This appears to be the first demonstration of neutrophil chemotactic activity liberated during the late TDI reaction in humans. The results are explained by an acute inflammatory process occurring during the late asthmatic reaction induced by TDI.

摘要

在IgE介导和非IgE介导的哮喘患者中，血液中性粒细胞的激活已得到证实。这一事件似乎受到体液因子释放的调节。我们让12名甲苯二异氰酸酯（TDI）哮喘工人接受TDI激发试验。在迟发性哮喘反应期间，释放了一种针对正常中性粒细胞的血清趋化因子，并激活了哮喘患者的中性粒细胞。这似乎是首次证明人类在TDI迟发性反应期间释放中性粒细胞趋化活性。结果可通过TDI诱导的迟发性哮喘反应期间发生的急性炎症过程来解释。