Patterson R, Hargreave F E, Grammer L C, Harris K E, Dolovich J
Int Arch Allergy Appl Immunol. 1987;84(1):93-100. doi: 10.1159/000234404.
A series of workers with exposure to and respiratory symptoms from toluene diisocyanate (TDI) was compared with a group of exposed, asymptomatic workers and with normal controls using immunologic and clinical evaluations. Improved understanding of TDI-induced respiratory disease may best be achieved by categorizing the symptomatic workers into at least 3 and possibly 4 groups: immunologic TDI asthma; pre-existing chronic respiratory disease exacerbated or unaffected by TDI; asthma coincidental with TDI exposure, and possibly TDI respiratory disease secondary to toxic or inflammatory mechanisms.
通过免疫和临床评估，将一组接触甲苯二异氰酸酯（TDI）并出现呼吸道症状的工人与一组接触TDI但无症状的工人以及正常对照组进行了比较。对TDI诱发的呼吸道疾病的更好理解，最好通过将有症状的工人至少分为3组，可能分为4组来实现：免疫性TDI哮喘；由TDI加重或未受其影响的既往慢性呼吸道疾病；与TDI接触同时发生的哮喘，以及可能继发于毒性或炎症机制的TDI呼吸道疾病。
