Pollard Suzanne L, Lima John J, Mougey Edward, Romero Karina, Tarazona-Meza Carla, Tomaino Katherine, Guzmán Gary Malpartida, Hansel Nadia N, Checkley William
Division of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, Maryland; Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.
Center for Pharmacogenomics and Translational Research, Nemours Children's Health System, Jacksonville, Florida.
Ann Allergy Asthma Immunol. 2017 Jul;119(1):37-41. doi: 10.1016/j.anai.2017.04.021. Epub 2017 May 19.
Evidence suggests free mono-hydroxyvitamin D (25[OH]D) concentrations are more strongly linked to certain outcomes than total concentrations; however, no studies have examined the relation between free 25(OH)D and respiratory or allergic disease.
To examine associations between total and free 25(OH)D concentrations and asthma outcomes.
We quantified total and free 25(OH)D concentrations in 137 Peruvian children with asthma and 152 children without asthma and examined associations with asthma outcomes.
Mean age ± SD was 13 ± 2.5 years, and 50.2% were boys. Mean total and measured free 25(OH)D concentrations were 29 ± 9.5 ng/mL and 5.0 ± 1.3 pg/mL, respectively. Lower free but not total 25(OH)D concentrations were significantly associated with atopy in all children (total, odds ratio [OR] 1.3 per 10-ng/mL decrease, 95% confidence interval [CI] 0.95-1.7, P = .12; vs free, OR 1.3 per 1-pg/mL decrease, 95% CI 1.0-1.6, P = .02) and children with asthma (total, OR 1.1 per 10-ng/mL decrease, 95% CI 0.75-1.7, P = .57; vs free, OR 1.6 per 1-pg/mL decrease, 95% CI 1.0-2.5, P = .04). Free but not total 25(OH)D levels were significantly associated with pre-bronchodilator forced expiratory volume in 1 second (total, 0.11 L, -0.12 to 0.34, P = .34; vs free, 0.20 L, 0.021-0.39, P = .03) and forced vital capacity (total, 0.13 L, -0.12 to 0.37, P = .31; vs free, 0.22 L, 0.026-0.42, P = .03) Z-scores in children with asthma.
Atopy, forced expiratory volume in 1 second, and forced vital capacity were more strongly linked to free than to total 25(OH)D concentrations, suggesting the free form might be more relevant in modulating allergic disease risk and pulmonary function in children with asthma.
有证据表明，游离单羟基维生素D（25[OH]D）浓度与某些结果的关联比总浓度更强；然而，尚无研究探讨游离25(OH)D与呼吸系统或过敏性疾病之间的关系。
研究总25(OH)D浓度和游离25(OH)D浓度与哮喘结局之间的关联。
我们对137名患有哮喘的秘鲁儿童和152名未患哮喘的儿童的总25(OH)D浓度和游离25(OH)D浓度进行了量化，并研究了它们与哮喘结局的关联。
平均年龄±标准差为13±2.5岁，50.2%为男孩。平均总25(OH)D浓度和测得的游离25(OH)D浓度分别为29±9.5 ng/mL和5.0±1.3 pg/mL。在所有儿童中，较低的游离25(OH)D浓度而非总25(OH)D浓度与特应性显著相关（总浓度，每降低10 ng/mL的比值比[OR]为1.3，95%置信区间[CI]为0.95-1.7，P = 0.12；游离浓度，每降低1 pg/mL的OR为1.3，95% CI为1.0-1.6，P = 0.02），在患有哮喘的儿童中也是如此（总浓度，每降低10 ng/mL 的OR为1.1，95% CI为0.75-1.7，P = 0.57；游离浓度，每降低1 pg/mL的OR为1.6，95% CI为1.0-2.5，P = 0.04）。在患有哮喘的儿童中，游离25(OH)D水平而非总25(OH)D水平与支气管扩张剂使用前1秒用力呼气量显著相关（总浓度，0.11 L，-0.12至0.34，P = 0.34；游离浓度，0.20 L，0.021-0.39，P = 0.03）以及用力肺活量（总浓度，0.13 L，-0.12至0.37，P = 0.31；游离浓度，0.2 L，0.026-0.42，P = 0.03）的Z评分。
特应性、1秒用力呼气量和用力肺活量与游离25(OH)D浓度的关联比与总25(OH)D浓度的关联更强，这表明游离形式可能在调节哮喘儿童的过敏性疾病风险和肺功能方面更具相关性。
