早期生活环境在过敏性疾病发展中的作用。
The role of the early-life environment in the development of allergic disease.
作者信息
Wegienka Ganesa, Zoratti Edward, Johnson Christine Cole
机构信息
Department of Public Health Sciences, Henry Ford Hospital, Detroit, MI, USA.
Division of Allergy and Immunology, Department of Internal Medicine, Henry Ford Hospital, Detroit, MI, USA.
出版信息
Immunol Allergy Clin North Am. 2015 Feb;35(1):1-17. doi: 10.1016/j.iac.2014.09.002. Epub 2014 Oct 18.
Abstract
A consensus has been reached that the development of allergic disorders is strongly influenced by early life exposures. An overview of several prenatal and early life factors that have been investigated for their associations with development of childhood allergy is presented. Delivery mode, the gut microbiome, vitamin D, folate, breastfeeding, pets, antibiotics, environmental tobacco smoke, and airborne traffic pollutants are discussed. Although many studies suggest an effect, overall, no risk factors clearly increase or reduce the risk of allergic outcomes.
摘要
已达成共识，即过敏性疾病的发展受到生命早期暴露的强烈影响。本文概述了几种已被研究其与儿童过敏发展相关性的产前和生命早期因素。讨论了分娩方式、肠道微生物群、维生素D、叶酸、母乳喂养、宠物、抗生素、环境烟草烟雾和空气传播的交通污染物。尽管许多研究表明存在影响，但总体而言，没有危险因素能明确增加或降低过敏结局的风险。
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