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本文引用的文献

1
Atopic phenotypes identified with latent class analyses at age 2 years.2岁时通过潜在类别分析确定的特应性表型。
J Allergy Clin Immunol. 2014 Sep;134(3):722-727.e2. doi: 10.1016/j.jaci.2014.01.022. Epub 2014 Mar 15.
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Consequences of antibiotics and infections in infancy: bugs, drugs, and wheezing.婴儿期抗生素和感染的后果：细菌、药物和喘息。
Ann Allergy Asthma Immunol. 2014 May;112(5):441-445.e1. doi: 10.1016/j.anai.2014.01.022. Epub 2014 Mar 13.
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Early-life determinants of asthma from birth to age 20 years: a German birth cohort study.从出生到 20 岁的哮喘的生命早期决定因素：一项德国出生队列研究。
J Allergy Clin Immunol. 2014 Apr;133(4):979-88. doi: 10.1016/j.jaci.2013.11.035. Epub 2014 Jan 22.
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Developmental biology: Support mothers to secure future public health.发育生物学：支持母亲保障未来公众健康。
Nature. 2013 Dec 12;504(7479):209-11. doi: 10.1038/504209a.
5
Challenges in identifying asthma subgroups using unsupervised statistical learning techniques.使用无监督统计学习技术识别哮喘亚组面临的挑战。
Am J Respir Crit Care Med. 2013 Dec 1;188(11):1303-12. doi: 10.1164/rccm.201304-0694OC.
6
Breastfeeding and introduction of complementary foods during infancy in relation to the risk of asthma and atopic diseases up to 10 years.婴儿期母乳喂养和补充食品的引入与 10 岁前哮喘和特应性疾病风险的关系。
Clin Exp Allergy. 2013 Nov;43(11):1263-73. doi: 10.1111/cea.12180.
7
Association of tobacco smoke exposure and atopic sensitization.烟草烟雾暴露与特应性致敏的关联。
Ann Allergy Asthma Immunol. 2013 Nov;111(5):387-90. doi: 10.1016/j.anai.2013.07.023. Epub 2013 Aug 20.
8
Meta-analysis of air pollution exposure association with allergic sensitization in European birth cohorts.空气污染暴露与欧洲出生队列过敏致敏相关性的荟萃分析。
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9
Maternal 25-hydroxyvitamin D and its association with childhood atopic outcomes and lung function.母体 25-羟维生素 D 及其与儿童特应性结局和肺功能的关系。
Clin Exp Allergy. 2013 Oct;43(10):1180-8. doi: 10.1111/cea.12172.
10
Effects of tobacco smoke exposure in childhood on atopic diseases.儿童时期暴露于烟草烟雾对特应性疾病的影响。
Curr Allergy Asthma Rep. 2013 Dec;13(6):687-92. doi: 10.1007/s11882-013-0389-1.

早期生活环境在过敏性疾病发展中的作用。

The role of the early-life environment in the development of allergic disease.

作者信息

Wegienka Ganesa, Zoratti Edward, Johnson Christine Cole

机构信息

Department of Public Health Sciences, Henry Ford Hospital, Detroit, MI, USA.

Division of Allergy and Immunology, Department of Internal Medicine, Henry Ford Hospital, Detroit, MI, USA.

出版信息

Immunol Allergy Clin North Am. 2015 Feb;35(1):1-17. doi: 10.1016/j.iac.2014.09.002. Epub 2014 Oct 18.

DOI:10.1016/j.iac.2014.09.002
PMID:25459574
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4427897/
Abstract

A consensus has been reached that the development of allergic disorders is strongly influenced by early life exposures. An overview of several prenatal and early life factors that have been investigated for their associations with development of childhood allergy is presented. Delivery mode, the gut microbiome, vitamin D, folate, breastfeeding, pets, antibiotics, environmental tobacco smoke, and airborne traffic pollutants are discussed. Although many studies suggest an effect, overall, no risk factors clearly increase or reduce the risk of allergic outcomes.

摘要

已达成共识，即过敏性疾病的发展受到生命早期暴露的强烈影响。本文概述了几种已被研究其与儿童过敏发展相关性的产前和生命早期因素。讨论了分娩方式、肠道微生物群、维生素D、叶酸、母乳喂养、宠物、抗生素、环境烟草烟雾和空气传播的交通污染物。尽管许多研究表明存在影响，但总体而言，没有危险因素能明确增加或降低过敏结局的风险。