• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

增强子衍生RNA：入门指南。

Enhancer-derived RNA: A Primer.

作者信息

Liu Feng

机构信息

National Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

出版信息

Genomics Proteomics Bioinformatics. 2017 Jun;15(3):196-200. doi: 10.1016/j.gpb.2016.12.006. Epub 2017 May 19.

DOI:10.1016/j.gpb.2016.12.006
PMID:28533025
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5487531/
Abstract

Enhancer-derived RNAs (eRNAs) are a group of RNAs transcribed by RNA polymerase II from the domain of transcription enhancers, a major type of cis-regulatory elements in the genome. The correlation between eRNA production and enhancer activity has stimulated studies on the potential role of eRNAs in transcriptional regulation. Additionally, eRNA has also served as a marker for global identification of enhancers. Here I review the brief history and fascinating properties of eRNAs.

摘要

增强子衍生RNA（eRNAs）是一组由RNA聚合酶II从转录增强子区域转录而来的RNA，转录增强子是基因组中一种主要的顺式调控元件。eRNA产生与增强子活性之间的相关性激发了人们对eRNAs在转录调控中潜在作用的研究。此外，eRNA还作为增强子全基因组识别的标志物。在此，我将综述eRNAs的简短历史和迷人特性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43c8/5487531/ee4bd24d9b70/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43c8/5487531/ee4bd24d9b70/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43c8/5487531/ee4bd24d9b70/gr1.jpg

相似文献

1
Enhancer-derived RNA: A Primer.增强子衍生RNA：入门指南。
Genomics Proteomics Bioinformatics. 2017 Jun;15(3):196-200. doi: 10.1016/j.gpb.2016.12.006. Epub 2017 May 19.
2
Non-coding RNA derived from the region adjacent to the human HO-1 E2 enhancer selectively regulates HO-1 gene induction by modulating Pol II binding.源自人HO-1 E2增强子相邻区域的非编码RNA通过调节RNA聚合酶II结合来选择性调控HO-1基因的诱导。
Nucleic Acids Res. 2014 Dec 16;42(22):13599-614. doi: 10.1093/nar/gku1169. Epub 2014 Nov 17.
3
Enhancer RNAs step forward: new insights into enhancer function.增强子 RNA 崭露头角：对增强子功能的新见解。
Development. 2022 Aug 15;149(16). doi: 10.1242/dev.200398. Epub 2022 Aug 30.
4
Transcriptional control by enhancers and enhancer RNAs.增强子和增强子RNA的转录调控。
Transcription. 2019 Aug-Oct;10(4-5):171-186. doi: 10.1080/21541264.2019.1695492. Epub 2019 Dec 2.
5
Insights into Enhancer RNAs: Biogenesis and Emerging Role in Brain Diseases.增强子RNA的研究进展：生物发生及其在脑部疾病中的新作用
Neuroscientist. 2023 Apr;29(2):166-176. doi: 10.1177/10738584211046889. Epub 2021 Oct 6.
6
Enhancer RNA: biogenesis, function, and regulation.增强子 RNA：生物发生、功能和调控。
Essays Biochem. 2020 Dec 7;64(6):883-894. doi: 10.1042/EBC20200014.
7
Enhancer RNAs and regulated transcriptional programs.增强子RNA与调控转录程序
Trends Biochem Sci. 2014 Apr;39(4):170-82. doi: 10.1016/j.tibs.2014.02.007. Epub 2014 Mar 24.
8
Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation.增强子 RNA 在雌激素依赖性转录激活中的功能作用。
Nature. 2013 Jun 27;498(7455):516-20. doi: 10.1038/nature12210. Epub 2013 Jun 2.
9
Genome-wide analysis of enhancer RNA in gene regulation across 12 mouse tissues.12种小鼠组织中增强子RNA在基因调控中的全基因组分析。
Sci Rep. 2015 Jul 29;5:12648. doi: 10.1038/srep12648.
10
Differential activity of transcribed enhancers in the prefrontal cortex of 537 cases with schizophrenia and controls.转录增强子在精神分裂症患者和对照者前额叶皮层中的差异活性。537 例病例。
Mol Psychiatry. 2019 Nov;24(11):1685-1695. doi: 10.1038/s41380-018-0059-8. Epub 2018 May 8.

引用本文的文献

1
Non-Coding RNAs in Cancer: Structure, Function, and Clinical Application.癌症中的非编码RNA：结构、功能及临床应用
Cancers (Basel). 2025 Feb 8;17(4):579. doi: 10.3390/cancers17040579.
2
Cis-Regulatory Elements in Mammals.哺乳动物中的顺式调控元件。
Int J Mol Sci. 2023 Dec 26;25(1):343. doi: 10.3390/ijms25010343.
3
Predicting active enhancers with DNA methylation and histone modification.利用 DNA 甲基化和组蛋白修饰预测活性增强子。

本文引用的文献

1
Epstein-Barr virus super-enhancer eRNAs are essential for MYC oncogene expression and lymphoblast proliferation.爱泼斯坦-巴尔病毒超级增强子eRNA对MYC癌基因表达和淋巴母细胞增殖至关重要。
Proc Natl Acad Sci U S A. 2016 Dec 6;113(49):14121-14126. doi: 10.1073/pnas.1616697113. Epub 2016 Nov 18.
2
Identification of Transcribed Enhancers by Genome-Wide Chromatin Immunoprecipitation Sequencing.通过全基因组染色质免疫沉淀测序鉴定转录增强子
Methods Mol Biol. 2017;1468:91-109. doi: 10.1007/978-1-4939-4035-6_8.
3
Visualization of Enhancer-Derived Noncoding RNA.
BMC Bioinformatics. 2023 Nov 2;24(1):414. doi: 10.1186/s12859-023-05547-y.
4
Mapping the epigenomic landscape of human monocytes following innate immune activation reveals context-specific mechanisms driving endotoxin tolerance.绘制人类单核细胞固有免疫激活后表观基因组图谱揭示了驱动内毒素耐受的特定于上下文的机制。
BMC Genomics. 2023 Oct 7;24(1):595. doi: 10.1186/s12864-023-09663-0.
5
Emerging Role of Enhancer RNAs as Potential Diagnostic and Prognostic Biomarkers in Cancer.增强子RNA作为癌症潜在诊断和预后生物标志物的新兴作用
Noncoding RNA. 2022 Oct 1;8(5):66. doi: 10.3390/ncrna8050066.
6
Different transcriptional responses by the CRISPRa system in distinct types of heterochromatin in Drosophila melanogaster.CRISPRa 系统在果蝇不同类型异染色质中的不同转录反应。
Sci Rep. 2022 Jul 9;12(1):11702. doi: 10.1038/s41598-022-15944-7.
7
Identification and characteristic analysis of enhancers across 13 major cancer types.13种主要癌症类型中增强子的鉴定与特征分析
Precis Clin Med. 2021 Aug 2;4(3):204-208. doi: 10.1093/pcmedi/pbab019. eCollection 2021 Sep.
8
Enhancer RNA LINC00242-Induced Expression of PHF10 Drives a Better Prognosis in Pancreatic Adenocarcinoma.增强子RNA LINC00242诱导的PHF10表达改善胰腺腺癌的预后。
Front Oncol. 2022 Jan 20;11:795090. doi: 10.3389/fonc.2021.795090. eCollection 2021.
9
LncRNA AC007255.1, an immune-related prognostic enhancer RNA in esophageal cancer.长链非编码RNA AC007255.1，一种食管癌中与免疫相关的预后增强子RNA。
PeerJ. 2021 Jul 14;9:e11698. doi: 10.7717/peerj.11698. eCollection 2021.
10
The Role of Long Non-Coding RNAs in Trophoblast Regulation in Preeclampsia and Intrauterine Growth Restriction.长链非编码 RNA 在子痫前期和宫内生长受限中对滋养层调节的作用。
Genes (Basel). 2021 Jun 25;12(7):970. doi: 10.3390/genes12070970.
增强子衍生的非编码RNA的可视化
Methods Mol Biol. 2017;1468:19-32. doi: 10.1007/978-1-4939-4035-6_3.
4
Knockdown of Nuclear-Located Enhancer RNAs and Long ncRNAs Using Locked Nucleic Acid GapmeRs.使用锁核酸GapmeRs敲低核定位增强子RNA和长链非编码RNA
Methods Mol Biol. 2017;1468:11-8. doi: 10.1007/978-1-4939-4035-6_2.
5
Advances in the characterization of RNA-binding proteins.RNA结合蛋白表征方面的进展。
Wiley Interdiscip Rev RNA. 2016 Nov;7(6):793-810. doi: 10.1002/wrna.1378. Epub 2016 Aug 8.
6
Base-pair-resolution genome-wide mapping of active RNA polymerases using precision nuclear run-on (PRO-seq).使用精确核运行（PRO-seq）进行全基因组范围内活性 RNA 聚合酶的碱基对分辨率作图。
Nat Protoc. 2016 Aug;11(8):1455-76. doi: 10.1038/nprot.2016.086. Epub 2016 Jul 21.
7
Nuclear Noncoding RNAs and Genome Stability.核非编码RNA与基因组稳定性
Mol Cell. 2016 Jul 7;63(1):7-20. doi: 10.1016/j.molcel.2016.06.011.
8
Greater Than the Sum of Parts: Complexity of the Dynamic Epigenome.大于部分之和：动态表观基因组的复杂性
Mol Cell. 2016 Jun 2;62(5):681-94. doi: 10.1016/j.molcel.2016.05.004.
9
Alterations of androgen receptor-regulated enhancer RNAs (eRNAs) contribute to enzalutamide resistance in castration-resistant prostate cancer.雄激素受体调控的增强子RNA（eRNAs）的改变促成去势抵抗性前列腺癌对恩杂鲁胺的耐药。
Oncotarget. 2016 Jun 21;7(25):38551-38565. doi: 10.18632/oncotarget.9535.
10
CRISPR/Cas9 in Genome Editing and Beyond.CRISPR/Cas9 在基因组编辑及其他领域的应用
Annu Rev Biochem. 2016 Jun 2;85:227-64. doi: 10.1146/annurev-biochem-060815-014607. Epub 2016 Apr 25.