大于部分之和：动态表观基因组的复杂性
Greater Than the Sum of Parts: Complexity of the Dynamic Epigenome.
作者信息
Soshnev Alexey A, Josefowicz Steven Z, Allis C David
机构信息
Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, NY 10065, USA.
Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, NY 10065, USA.
出版信息
Mol Cell. 2016 Jun 2;62(5):681-94. doi: 10.1016/j.molcel.2016.05.004.
Abstract
Information encoded in DNA is interpreted, modified, and propagated as chromatin. The diversity of inputs encountered by eukaryotic genomes demands a matching capacity for transcriptional outcomes provided by the combinatorial and dynamic nature of epigenetic processes. Advances in genome editing, visualization technology, and genome-wide analyses have revealed unprecedented complexity of chromatin pathways, offering explanations to long-standing questions and presenting new challenges. Here, we review recent findings, exemplified by the emerging understanding of crossregulatory interactions within chromatin, and emphasize the pathologic outcomes of epigenetic misregulation in cancer.
摘要
DNA中编码的信息作为染色质被解读、修饰和传递。真核生物基因组所遇到的输入多样性要求由表观遗传过程的组合性和动态性提供相匹配的转录结果能力。基因组编辑、可视化技术和全基因组分析的进展揭示了染色质途径前所未有的复杂性，为长期存在的问题提供了解释，并带来了新的挑战。在这里，我们回顾了最近的发现，以对染色质内交叉调节相互作用的新认识为例，并强调了癌症中表观遗传失调的病理结果。
相似文献
1
Greater Than the Sum of Parts: Complexity of the Dynamic Epigenome.大于部分之和：动态表观基因组的复杂性
Mol Cell. 2016 Jun 2;62(5):681-94. doi: 10.1016/j.molcel.2016.05.004.
2
Cancer: an epigenetic landscape.癌症：一种表观遗传景观。
Subcell Biochem. 2013;61:399-417. doi: 10.1007/978-94-007-4525-4_17.
3
Epigenetic regulation of cancer stem cell gene expression.癌症干细胞基因表达的表观遗传调控。
Subcell Biochem. 2013;61:419-34. doi: 10.1007/978-94-007-4525-4_18.
4
DNA methylation and histone modifications in patients with cancer: potential prognostic and therapeutic targets.癌症患者的DNA甲基化和组蛋白修饰：潜在的预后和治疗靶点。
Methods Mol Biol. 2007;361:25-62. doi: 10.1385/1-59745-208-4:25.
5
Epigenetic drugs as pleiotropic agents in cancer treatment: biomolecular aspects and clinical applications.表观遗传药物作为癌症治疗中的多效性药物：生物分子方面及临床应用
J Cell Physiol. 2007 Aug;212(2):330-44. doi: 10.1002/jcp.21066.
6
Epigenetics and MicroRNAs in Cancer.癌症中的表观遗传学和 microRNAs。
Int J Mol Sci. 2018 Feb 3;19(2):459. doi: 10.3390/ijms19020459.
7
Epigenetic changes in cancer.癌症中的表观遗传变化。
Annu Rev Pathol. 2009;4:229-49. doi: 10.1146/annurev.pathol.3.121806.151442.
8
Epigenetic tête-à-tête: the bilateral relationship between chromatin modifications and DNA methylation.表观遗传学的深入探讨：染色质修饰与DNA甲基化之间的双向关系
Biochem Cell Biol. 2006 Aug;84(4):463-76. doi: 10.1139/o06-090.
9
Molecular biology. Genetic events that shape the cancer epigenome.分子生物学。塑造癌症表观基因组的遗传事件。
Science. 2012 Jun 22;336(6088):1513-4. doi: 10.1126/science.1223730.
10
Cancer induction and suppression with transcriptional control and epigenome editing technologies.利用转录控制和表观基因组编辑技术诱导和抑制癌症。
J Hum Genet. 2018 Feb;63(2):187-194. doi: 10.1038/s10038-017-0377-8. Epub 2017 Nov 14.
引用本文的文献
1
Epigenetic Modifications in the Retinal Pigment Epithelium of the Eye During RPE-Related Regeneration or Retinal Diseases in Vertebrates.脊椎动物视网膜色素上皮相关再生或视网膜疾病期间眼部视网膜色素上皮中的表观遗传修饰
Biomedicines. 2025 Jun 25;13(7):1552. doi: 10.3390/biomedicines13071552.
2
Histone H3 cysteine 110 enhances iron metabolism and modulates replicative life span in .组蛋白H3半胱氨酸110增强铁代谢并调节（此处原文似乎不完整，缺少具体对象）的复制寿命。
Sci Adv. 2025 Apr 11;11(15):eadv4082. doi: 10.1126/sciadv.adv4082.
3
Genomic context-dependent histone H3K36 methylation by three Drosophila methyltransferases and implications for dedicated chromatin readers.三种果蝇甲基转移酶介导的基因组背景依赖性组蛋白H3K36甲基化及其对特定染色质阅读器的影响
Nucleic Acids Res. 2025 Mar 20;53(6). doi: 10.1093/nar/gkaf202.
4
Chromatin remodeling protein BPTF mediates chromatin accessibility at gene promoters in planarian stem cells.染色质重塑蛋白BPTF介导涡虫干细胞中基因启动子处的染色质可及性。
BMC Genomics. 2025 Mar 11;26(1):232. doi: 10.1186/s12864-025-11405-3.
5
Polycomb repressive complex 2 (PRC2) pathway's role in cancer cell plasticity and drug resistance.多梳抑制复合物2（PRC2）通路在癌细胞可塑性和耐药性中的作用。
Funct Integr Genomics. 2025 Mar 6;25(1):53. doi: 10.1007/s10142-025-01563-8.
6
Epigene functional diversity: isoform usage, disordered domain content, and variable binding partners.表观遗传功能多样性：异构体使用、无序结构域含量和可变结合伴侣。
Epigenetics Chromatin. 2025 Feb 1;18(1):8. doi: 10.1186/s13072-025-00571-z.
7
Designing Epigenome Editors: Considerations of Biochemical and Locus Specificities.设计表观基因组编辑工具：考虑生化特性和基因座特异性。
Methods Mol Biol. 2024;2842:23-55. doi: 10.1007/978-1-0716-4051-7_2.
8
Genomic context-dependent histone H3K36 methylation by three Drosophila methyltransferases and implications for dedicated chromatin readers.依赖基因组背景的三种果蝇甲基转移酶的组蛋白 H3K36 甲基化及其对专用染色质阅读器的影响。
Nucleic Acids Res. 2024 Jul 22;52(13):7627-7649. doi: 10.1093/nar/gkae449.
9
Emerging Insights into the Role of BDNF on Health and Disease in Periphery.脑源性神经营养因子在外周健康与疾病中作用的新见解
Biomolecules. 2024 Apr 5;14(4):444. doi: 10.3390/biom14040444.
10
Bivalent chromatin: a developmental balancing act tipped in cancer.二价染色质：一种在癌症中失衡的发育平衡行为。
Biochem Soc Trans. 2024 Feb 28;52(1):217-229. doi: 10.1042/BST20230426.
本文引用的文献
1
Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape.组蛋白H3K36突变通过改变组蛋白甲基化格局促进肉瘤发生。
Science. 2016 May 13;352(6287):844-9. doi: 10.1126/science.aac7272.
2
The BAH domain of BAHD1 is a histone H3K27me3 reader.BAHD1的BAH结构域是一种组蛋白H3K27me3阅读器。
Protein Cell. 2016 Mar;7(3):222-6. doi: 10.1007/s13238-016-0243-z.
3
Histone H3.5 forms an unstable nucleosome and accumulates around transcription start sites in human testis.组蛋白H3.5形成不稳定的核小体，并在人类睾丸的转录起始位点周围积累。
Epigenetics Chromatin. 2016 Jan 15;9:2. doi: 10.1186/s13072-016-0051-y. eCollection 2016.
4
Modulations of DNA Contacts by Linker Histones and Post-translational Modifications Determine the Mobility and Modifiability of Nucleosomal H3 Tails.连接组蛋白和翻译后修饰对DNA接触的调控决定了核小体H3尾巴的流动性和可修饰性。
Mol Cell. 2016 Jan 21;61(2):247-59. doi: 10.1016/j.molcel.2015.12.015. Epub 2016 Jan 14.
5
Super-resolution imaging reveals distinct chromatin folding for different epigenetic states.超分辨率成像揭示了不同表观遗传状态下独特的染色质折叠。
Nature. 2016 Jan 21;529(7586):418-22. doi: 10.1038/nature16496. Epub 2016 Jan 13.
6
Insulator dysfunction and oncogene activation in IDH mutant gliomas.异柠檬酸脱氢酶（IDH）突变型胶质瘤中的绝缘子功能障碍与癌基因激活
Nature. 2016 Jan 7;529(7584):110-4. doi: 10.1038/nature16490. Epub 2015 Dec 23.
7
Loss of HP1 causes depletion of H3K27me3 from facultative heterochromatin and gain of H3K27me2 at constitutive heterochromatin.HP1的缺失导致兼性异染色质中H3K27me3的耗竭以及组成型异染色质中H3K27me2的增加。
Genome Res. 2016 Jan;26(1):97-107. doi: 10.1101/gr.194555.115. Epub 2015 Nov 4.
8
Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage.组蛋白 H1 可将泛素信号的起始和扩增偶联起来，以应对 DNA 损伤。
Nature. 2015 Nov 19;527(7578):389-93. doi: 10.1038/nature15401. Epub 2015 Oct 21.
9
Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2.活性多梳抑制复合物2介导组蛋白H3K27三甲基化的结构基础
Science. 2015 Oct 16;350(6258):aac4383. doi: 10.1126/science.aac4383. Epub 2015 Oct 15.
10
Recruitment and activation of the ATM kinase in the absence of DNA-damage sensors.在缺乏DNA损伤传感器的情况下ATM激酶的募集与激活。
Nat Struct Mol Biol. 2015 Sep;22(9):736-43. doi: 10.1038/nsmb.3072. Epub 2015 Aug 17.
Zotero 插件