Blocking CRMP2 SUMOylation reverses neuropathic pain.
作者信息
Moutal A, Dustrude E T, Largent-Milnes T M, Vanderah T W, Khanna M, Khanna R
机构信息
Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, USA.
Department of Anesthesiology, College of Medicine, University of Arizona, Tucson, AZ, USA.
出版信息
Mol Psychiatry. 2018 Nov;23(11):2119-2121. doi: 10.1038/mp.2017.117.
Abstract
摘要
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Hierarchical CRMP2 posttranslational modifications control NaV1.7 function.分层的CRMP2翻译后修饰控制NaV1.7功能。
Proc Natl Acad Sci U S A. 2016 Dec 27;113(52):E8443-E8452. doi: 10.1073/pnas.1610531113. Epub 2016 Dec 8.
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Mouse pups lacking collapsin response mediator protein 4 manifest impaired olfactory function and hyperactivity in the olfactory bulb.缺乏塌陷反应介导蛋白4的幼鼠表现出嗅觉功能受损以及嗅球多动。
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CRMPs: critical molecules for neurite morphogenesis and neuropsychiatric diseases.CRMPs：神经突形态发生和神经精神疾病的关键分子。
Mol Psychiatry. 2015 Sep;20(9):1037-45. doi: 10.1038/mp.2015.77. Epub 2015 Jun 16.
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Mice lacking collapsin response mediator protein 1 manifest hyperactivity, impaired learning and memory, and impaired prepulse inhibition.缺乏塌陷反应介导蛋白1的小鼠表现出多动、学习和记忆受损以及前脉冲抑制受损。
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