Kirkham T C, Cooper S J
Department of Psychology, University of Birmingham, England.
Physiol Behav. 1988;43(6):845-7. doi: 10.1016/0031-9384(88)90386-1.
The time course of the suppressive action of naloxone on sham feeding was examined in gastric fistulated rats. One hour sham intake of 30% sucrose solution was halved by 1.25 mg/kg IP (-)-naloxone. A maximal 75% reduction was obtained with 2.5 mg/kg. Naloxone's effect appeared to mimic the attenuation of intake rate produced by sucrose dilution. The stereoisomer (+)-naloxone (1.25, 2.5 and 10 mg/kg IP) was ineffective. These data confirm the involvement of opioid receptors in naloxone anorexia and are consistent with opioid involvement in the rewarding aspects of ingestion.
在胃造瘘大鼠中研究了纳洛酮对假饲抑制作用的时间进程。腹腔注射1.25mg/kg（-）-纳洛酮可使30%蔗糖溶液1小时的假摄入量减半。2.5mg/kg时最大减少量达75%。纳洛酮的作用似乎模拟了蔗糖稀释所产生的摄入速率衰减。立体异构体（+）-纳洛酮（腹腔注射1.25、2.5和10mg/kg）无效。这些数据证实了阿片受体参与纳洛酮所致厌食，并且与阿片类物质参与摄食的奖赏方面相一致。
