Xu Juanjuan, Fan Jinshuo, Wu Feng, Huang Qi, Guo Mengfei, Lv Zhilei, Han Jieli, Duan Limin, Hu Guorong, Chen Lian, Liao Tingting, Ma Wanli, Tao Xiaonan, Jin Yang
Key Laboratory of Respiratory Diseases of the Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyWuhan, China.
Front Physiol. 2017 May 8;8:276. doi: 10.3389/fphys.2017.00276. eCollection 2017.
Cancer remains one of the most common causes of death and disability and represents a major economic burden in industrialized nations. The renin-angiotensin system (RAS) has been well-recognized as one of the most important regulators of both normal and pathological physiological processes in the brain, kidney, heart, and blood vessels. The activation of the angiotensin-converting enzyme 2/angiotensin-(1-7)/mitochondrial assembly receptor [ACE2/Ang-(1-7)/MasR] axis, which is one component of the RAS, has recently been identified as a critical component of pulmonary systems, gastric mucosa, and cancer. However, the ability of the ACE2/Ang-(1-7)/MasR axis to suppress or promote cancer has not been fully elucidated. In this review, we focus on recent experimental and clinical studies investigating the basic properties, roles, and mechanisms of ACE2, Ang-(1-7), and the MasR, as well as the axis pathway, to provide insights into possible therapeutic strategies for treating cancer that target the ACE2/Ang-(1-7)/MasR axis.
癌症仍然是最常见的死亡和致残原因之一，在工业化国家构成重大经济负担。肾素-血管紧张素系统（RAS）已被公认为是大脑、肾脏、心脏和血管正常及病理生理过程最重要的调节系统之一。血管紧张素转换酶2/血管紧张素-（1-7）/线粒体装配受体[ACE2/Ang-（1-7）/MasR]轴是RAS的一个组成部分，最近已被确定为肺部系统、胃黏膜和癌症的关键组成部分。然而，ACE2/Ang-（1-7）/MasR轴抑制或促进癌症的能力尚未完全阐明。在这篇综述中，我们重点关注最近的实验和临床研究，这些研究探讨了ACE2、Ang-（1-7）和MasR的基本特性、作用和机制，以及轴通路，以便深入了解针对ACE2/Ang-（1-7）/MasR轴治疗癌症的可能策略。
