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[皮下黏液样脂肪肉瘤]

[Subcutaneous myxoid liposarcoma].

作者信息

Naim Asmâa, Benchekroune Nadia, Bouchbika Zineb, Taoufiq Nezha, Jouhadi Hassan, Sahraoui Souha, Benider Abdelatif

机构信息

CHU Ibn Rochd, Université Mohammed VI des Sciences de la Santé, Hopital Cheikh Khalifa, Casablanca, Maroc.

Centre Mohamed VI du Traitement du Cancer, Casablanca, Maroc.

出版信息

Pan Afr Med J. 2017 Mar 21;26:162. doi: 10.11604/pamj.2017.26.162.8494. eCollection 2017.

DOI:10.11604/pamj.2017.26.162.8494
PMID:28533883
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5429450/
Abstract

Although myxoid liposarcomas (MLS) are the most common type of soft-tissue sarcomas in adults, their primary location in the superficial tissues is rare. So sarcomas are classified as superficial and deep-seated. They are distinct based on their location and their frequency as well as their prognosis which is relatively better in superficial sarcomas. We here report the case of a patient with subcutaneous liposarcoma in the right thigh. The diagnosis was confirmed by histology after clinical symptoms had evolved over 1 year. Treatment involved wide surgical resection followed by locoregional radiation therapy. Patient's evolution was marked by complete remission maintained after 32 months follow-up. This study highlights that superficial sarcomas are rare and this can cause a delay in diagnosis compromising their prognosis.

摘要

尽管黏液样脂肪肉瘤(MLS)是成人中最常见的软组织肉瘤类型,但其主要位于浅表组织的情况较为罕见。肉瘤可分为浅表型和深部型。它们在位置、发生频率以及预后方面有所不同,浅表型肉瘤的预后相对较好。我们在此报告一例右大腿皮下脂肪肉瘤患者的病例。临床症状出现超过1年后,经组织学检查确诊。治疗包括广泛手术切除,随后进行局部区域放射治疗。患者在32个月的随访后维持完全缓解,病情进展良好。本研究强调浅表型肉瘤较为罕见,这可能导致诊断延迟,从而影响其预后。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5163/5429450/29c0eca4038a/PAMJ-26-162-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5163/5429450/dceb3305e599/PAMJ-26-162-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5163/5429450/1a69bd41cb50/PAMJ-26-162-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5163/5429450/29c0eca4038a/PAMJ-26-162-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5163/5429450/dceb3305e599/PAMJ-26-162-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5163/5429450/1a69bd41cb50/PAMJ-26-162-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5163/5429450/29c0eca4038a/PAMJ-26-162-g003.jpg

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本文引用的文献

1
Primary subcutaneous myxoid liposarcoma: a clinicopathologic review of three cases with molecular confirmation and discussion of the differential diagnosis.原发性皮下黏液样脂肪肉瘤:3例临床病理分析并经分子学证实及鉴别诊断讨论
J Cutan Pathol. 2014 Dec;41(12):907-15. doi: 10.1111/cup.12428. Epub 2014 Dec 5.
2
Subcutaneous myxoid and round cell liposarcoma.皮下黏液样和圆形细胞脂肪肉瘤
Ann Dermatol. 2011 Aug;23(3):338-41. doi: 10.5021/ad.2011.23.3.338. Epub 2011 Aug 6.
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[Primary myxoid mediastinal liposarcoma].[原发性黏液样纵隔脂肪肉瘤]
Rev Mal Respir. 2011 Jan;28(1):84-7. doi: 10.1016/j.rmr.2010.05.019. Epub 2011 Jan 11.
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Liposarcoma of the extremities: MR imaging features and their correlation with pathologic data.四肢脂肪肉瘤:MR 成像特征及其与病理数据的相关性。
Orthop Traumatol Surg Res. 2010 Dec;96(8):876-83. doi: 10.1016/j.otsr.2010.05.010. Epub 2010 Oct 12.
5
Superficial soft tissue sarcomas (S-STS): a study of 367 patients from the French Sarcoma Group (FSG) database.浅表软组织肉瘤(S-STS):一项对法国肉瘤研究组(FSG)数据库中367例患者的研究。
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Cutaneous and subcutaneous sarcomas.皮肤和皮下肉瘤。
Clin Dermatol. 2001 May-Jun;19(3):262-8. doi: 10.1016/s0738-081x(01)00177-8.
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Primary liposarcoma of the skin: a rare neoplasm with unusual high grade features.皮肤原发性脂肪肉瘤:一种具有罕见高级别特征的肿瘤。
Am J Dermatopathol. 1998 Aug;20(4):332-8. doi: 10.1097/00000372-199808000-00002.
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Liposarcoma: outcome and prognostic factors following conservation surgery and radiation therapy.脂肪肉瘤:保肢手术和放射治疗后的结局及预后因素
Int J Radiat Oncol Biol Phys. 1996 Sep 1;36(2):311-9. doi: 10.1016/s0360-3016(96)00265-9.
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Prognostic factors in adult patients with locally controlled soft tissue sarcoma. A study of 546 patients from the French Federation of Cancer Centers Sarcoma Group.成年局部控制软组织肉瘤患者的预后因素。对法国癌症中心肉瘤研究组的546例患者进行的研究。
J Clin Oncol. 1996 Mar;14(3):869-77. doi: 10.1200/JCO.1996.14.3.869.