Department of Internal Medicine, Division of Medical Oncology, Washington University School of Medicine, Box 8076 660 S. Euclid Avenue, St. Louis, MO, 63110, USA.
Siteman Cancer Center, Washington University School of Medicine, Saint Louis, MO, USA.
Curr Treat Options Oncol. 2018 Oct 25;19(12):64. doi: 10.1007/s11864-018-0590-5.
Sarcomas are a heterogeneous group of rare malignancies that arise from mesenchymal cells and can occur anywhere in the body. Herein, the focus will be on one subtype of sarcoma that arises from adipocytic tissue, liposarcoma. Specifically, the review will focus on one type of liposarcoma, myxoid liposarcoma. Given the rarity of this tumor, it is imperative that these patients are treated at a sarcoma center, where a multidisciplinary approach incorporates all the modalities available including clinical trials. As the understanding of the biology of myxoid liposarcomas progresses, more targeted therapies are being developed that will lead to better tolerated treatments and improved survival for patients. In this review, we will be discussing the pathophysiology, clinical presentation, diagnostic workup, and available treatment options including surgery, radiation, chemotherapy, and clinical trials.
肉瘤是一组源自间叶细胞的罕见恶性肿瘤，可发生在身体的任何部位。本文将重点介绍一种源自脂肪组织的肉瘤，即脂肪肉瘤。具体而言，本综述将聚焦于一种脂肪肉瘤，黏液样脂肪肉瘤。鉴于这种肿瘤的罕见性，至关重要的是，这些患者在肉瘤中心接受治疗，肉瘤中心采用多学科方法结合所有可用的治疗手段，包括临床试验。随着对黏液样脂肪肉瘤生物学的理解不断深入，正在开发更具针对性的治疗方法，这将导致更好耐受的治疗方法和提高患者的生存率。在本综述中，我们将讨论黏液样脂肪肉瘤的病理生理学、临床表现、诊断方法以及手术、放疗、化疗和临床试验等可用的治疗选择。
