De Togni P, Fox E S, Morrissey S, Babior B M, Levy S B
Department of Medicine, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111.
Plasmid. 1988 Sep;20(2):143-7. doi: 10.1016/0147-619x(88)90017-0.
A spontaneous mutation in pUC18 has revealed the insertion of a chromosomal insertion sequence (IS)2 element into the promoter region of the lac operon. The IS2 insertion site, at the pentanucleotide sequence TCGAG, is unlike previously described junctional sequences.
pUC18中的一个自发突变显示，一个染色体插入序列（IS）2元件插入到了乳糖操纵子的启动子区域。IS2的插入位点位于五核苷酸序列TCGAG处，与先前描述的连接序列不同。
