Cross J A, Cheetham S C, Crompton M R, Katona C L, Horton R W
Department of Pharmacology & Clinical Pharmacology, St. George's Hospital Medical School, London.
Psychiatry Res. 1988 Nov;26(2):119-29. doi: 10.1016/0165-1781(88)90066-2.
Binding sites for gamma-aminobutyric acid, type B (GABAB), were measured in post-mortem brain samples (frontal cortex, temporal cortex, and hippocampus) from a group of suicide victims and a group of sex- and age-matched controls. Retrospective psychiatric diagnosis was performed, and only suicide victims with clear evidence of depression in the absence of symptoms of other psychiatric or neurological disorders were studied. There were no significant differences between depressed suicides and controls in the number or affinity of GABAB binding sites in the frontal or temporal cortex and no difference in GABAB binding (measured at two concentrations) in the hippocampus. Thirteen of the depressed suicides had not been prescribed antidepressant drugs recently, and none were found in their blood at postmortem. The number of GABAB binding sites in the frontal and temporal cortex and GABAB binding in the hippocampus did not differ significantly between these drug-free suicides and matched controls. The Kd was higher, however, in the temporal cortex of the drug-free suicides than in the controls. A significant negative correlation was found between age and the number of GABAB binding sites in the temporal cortex (on the basis of pooled data from suicides and controls). These results indicate that GABAB binding sites are unaltered in the brains of depressed suicide victims.
在一组自杀受害者以及一组性别和年龄匹配的对照者的尸检脑样本（额叶皮质、颞叶皮质和海马体）中，对B型γ-氨基丁酸（GABAB）的结合位点进行了测量。进行了回顾性精神病学诊断，仅研究了那些有明确抑郁症证据且无其他精神或神经疾病症状的自杀受害者。在额叶或颞叶皮质中，抑郁自杀者与对照者在GABAB结合位点的数量或亲和力方面没有显著差异，在海马体中，GABAB结合（在两种浓度下测量）也没有差异。13名抑郁自杀者近期未服用过抗抑郁药物，死后在其血液中也未检测到。这些未服用药物的自杀者与匹配的对照者相比，额叶和颞叶皮质中GABAB结合位点的数量以及海马体中GABAB结合情况没有显著差异。然而，未服用药物的自杀者颞叶皮质中的解离常数（Kd）高于对照者。在颞叶皮质中（基于自杀者和对照者的汇总数据），年龄与GABAB结合位点的数量之间存在显著的负相关。这些结果表明，抑郁自杀受害者大脑中的GABAB结合位点未发生改变。
