Arranz B, Cowburn R, Eriksson A, Vestling M, Marcusson J
Department of Geriatric Medicine, University of Linköping, Sweden.
Neuropsychobiology. 1992;26(1-2):33-6. doi: 10.1159/000118893.
Gamma-aminobutyric acid-B (GABAB) binding sites labelled with [3H]GABA were determined in postmortem frontal cortex samples of 20 control subjects and 16 suicides. The suicide group was further subdivided according to the method of suicide and the existence of depressive symptoms prior to death. No significant differences in GABAB binding were found either between overall suicide and control groups or between the control group and the other subgroups (violent suicide, nonviolent suicide, nondepressed and depressed suicide victims). A significant increase in GABAB binding was observed in those individuals dying from carbon monoxide poisoning. It is concluded that although GABAB binding sites are not altered in our suicide group, a presynaptic dysfunction might account for the increased GABAB binding found in the carbon monoxide subgroup.
在20名对照受试者和16名自杀者的死后额叶皮质样本中，测定了用[3H]GABA标记的γ-氨基丁酸B（GABAB）结合位点。自杀组根据自杀方式和死亡前抑郁症状的存在情况进一步细分。在总体自杀组与对照组之间，或对照组与其他亚组（暴力自杀、非暴力自杀、无抑郁和有抑郁的自杀受害者）之间，未发现GABAB结合有显著差异。在死于一氧化碳中毒的个体中，观察到GABAB结合显著增加。得出的结论是，虽然在我们的自杀组中GABAB结合位点没有改变，但突触前功能障碍可能是一氧化碳亚组中GABAB结合增加的原因。
