Asada Noboru, Takeishi Shoichiro, Frenette Paul S
Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, 1301 Morris Park Avenue, Bronx, NY, 10461, USA.
Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.
Int J Hematol. 2017 Jul;106(1):45-54. doi: 10.1007/s12185-017-2262-9. Epub 2017 May 22.
Hematopoietic stem cells (HSCs) that produce a variety of hematopoietic lineage cells throughout the life reside in specialized microenvironment called "niche" in the bone marrow (BM) where they are tightly regulated. With the recent advances in experimental technologies enabling the selective deletion of molecules, various types of cells in the BM have been proposed to contribute to HSC niche activity. Among these are stromal cells closely associated with the vasculature. In this review, we provide an overview of recent advances in HSC niche research, and focus on the studies describing the functional roles of perivascular cells for HSC maintenance and mobilization. Not only for physiologic state, we also discuss the recent evidences suggesting the importance of microenvironment for emergence of malignant hematopoietic diseases.
造血干细胞（HSCs）在整个生命过程中产生多种造血谱系细胞，它们存在于骨髓（BM）中一种称为“龛位”的特殊微环境中，在那里它们受到严格调控。随着能够选择性删除分子的实验技术的最新进展，有人提出骨髓中的各种类型细胞有助于造血干细胞龛位活动。其中包括与脉管系统密切相关的基质细胞。在这篇综述中，我们概述了造血干细胞龛位研究的最新进展，并重点关注描述血管周围细胞对造血干细胞维持和动员的功能作用的研究。不仅针对生理状态，我们还讨论了表明微环境对恶性造血疾病发生的重要性的最新证据。
