微小RNA-933变异体与胃癌易感性的关联。
Association of microRNA-933 variant with the susceptibility to gastric cancer.
作者信息
Zhang Yitong, Ma Yanyun, Xu Weihong, Li Wenshuai, Min Pei, Qiu Jigang, Li Min, Tang Feng, Zhang Mingqing, Yang Dongqin, Zhang Jun
机构信息
Department of Digestive Diseases, Huashan Hospital, Fudan University, Shanghai, China.
出版信息
J BUON. 2017 Mar-Apr;22(2):390-395.
PURPOSE
Common single-nucleotide polymorphisms (SNPs) in microRNAs (miRs) have been shown to be associated with susceptibility to several types of human cancer. However, the association of miR-933 rs79402775 with gastric cancer (GC) has not been explored.
METHODS
The association between rs79402775 in miR- 933 and the risk of GC was explored in Chinese population based on MassARRAY technology. A total 374 GC patients and 999 cancer-free controls were enrolled in this study.
RESULTS
Compared with the wild-type GG, GA genotype was associated with a significantly decreased risk of GC (OR=0.542, 95% CI=0.299-0.983, p=0.044) in female subjects. Moreover, the variant was also associated with the expression of alpha fetoprotein (AFP) and carcinoembryonic antigen (CEA).
CONCLUSIONS
miR-933(rs79402775) may contribute to decreased susceptibility to GC and this SNP could be developed as a biomarker for GC prognosis.
目的
微小RNA（miR）中的常见单核苷酸多态性（SNP）已被证明与多种人类癌症的易感性相关。然而，miR-933 rs79402775与胃癌（GC）的关联尚未得到探索。
方法
基于MassARRAY技术，在中国人群中探索miR-933中rs79402775与GC风险之间的关联。本研究共纳入374例GC患者和999例无癌对照。
结果
在女性受试者中，与野生型GG相比，GA基因型与GC风险显著降低相关（OR = 0.542，95% CI = 0.299 - 0.983，p = 0.044）。此外，该变异还与甲胎蛋白（AFP）和癌胚抗原（CEA）的表达相关。
结论
miR-933（rs79402775）可能有助于降低GC易感性，并且该SNP可开发为GC预后的生物标志物。
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