Hsa-miR-449a基因变异与中国人群患胃癌的风险相关。
Hsa-miR-449a genetic variant is associated with risk of gastric cancer in a Chinese population.
作者信息
Shi Jian, Liu Yangchen, Liu Jun, Zhou Juan
机构信息
Emzymological Institute, The Affiliated Hospital of Nantong University Nantong 226001, Jiangsu, China.
Department of Radiotherapy, Taixing People's Hospital Taixing 225400, Jiangsu, China.
出版信息
Int J Clin Exp Pathol. 2015 Oct 1;8(10):13387-92. eCollection 2015.
Abstract
Gastric cancer (GC) is one of the most common malignancies and one of the major causes of cancer-related deaths worldwide. In the present study, we investigated the association between miR-449a rs112310158 SNP and GC risk. Our findings revealed that a variant GG genotype increased the risk of occurrence of GC compared to a wild type AA genotype (OR = 2.542, 95% CI: 1.304-4.954, P = 0.005). Specifically, the G allele reduced the risk of occurrence of cervical cancer in women compared to the A allele (OR = 1.279, 95% CI: 1.012-1.617, P = 0.043). In conclusion, our findings suggest that miR-449a rs112310158 is a genetic risk factor for GC.
摘要
胃癌（GC）是最常见的恶性肿瘤之一，也是全球癌症相关死亡的主要原因之一。在本研究中，我们调查了miR-449a rs112310158单核苷酸多态性与胃癌风险之间的关联。我们的研究结果显示，与野生型AA基因型相比，变异型GG基因型增加了胃癌发生风险（比值比[OR]=2.542，95%置信区间[CI]：1.304-4.954，P=0.005）。具体而言，与A等位基因相比，G等位基因降低了女性患宫颈癌的风险（OR=1.279，95%CI：1.012-1.617，P=0.043）。总之，我们的研究结果表明，miR-449a rs112310158是胃癌的一个遗传风险因素。
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