Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri 63130, USA.
Nat Commun. 2017 May 23;8:15413. doi: 10.1038/ncomms15413.
Even simple sensory stimuli evoke neural responses that are dynamic and complex. Are the temporally patterned neural activities important for controlling the behavioral output? Here, we investigated this issue. Our results reveal that in the insect antennal lobe, due to circuit interactions, distinct neural ensembles are activated during and immediately following the termination of every odorant. Such non-overlapping response patterns are not observed even when the stimulus intensity or identities were changed. In addition, we find that ON and OFF ensemble neural activities differ in their ability to recruit recurrent inhibition, entrain field-potential oscillations and more importantly in their relevance to behaviour (initiate versus reset conditioned responses). Notably, we find that a strikingly similar strategy is also used for encoding sound onsets and offsets in the marmoset auditory cortex. In sum, our results suggest a general approach where recurrent inhibition is associated with stimulus 'recognition' and 'derecognition'.
即使是简单的感觉刺激也会引起动态而复杂的神经反应。时间模式的神经活动对控制行为输出重要吗？在这里，我们研究了这个问题。我们的结果表明，在昆虫触角叶中，由于电路相互作用，在每种气味剂终止时和终止后不久，都会激活不同的神经集合。即使改变了刺激强度或身份，也不会观察到这种不重叠的反应模式。此外，我们发现，ON 和 OFF 集合的神经活动在它们招募回返抑制、引发场电位振荡的能力方面存在差异，更重要的是，它们与行为的相关性（启动与重置条件反应）方面存在差异。值得注意的是，我们发现，在狨猴听觉皮层中，用于编码声音起始和结束的策略也惊人地相似。总之，我们的研究结果表明，一种普遍的策略是将回返抑制与刺激的“识别”和“去识别”联系起来。
