患有阿尔茨海默病及相关痴呆症的老年人的光照、睡眠与昼夜节律
Light, sleep and circadian rhythms in older adults with Alzheimer's disease and related dementias.
作者信息
Figueiro Mariana G
机构信息
Lighting Research Center, Rensselaer Polytechnic Institute, 21 Union Street, Troy, NY 12180, USA.
出版信息
Neurodegener Dis Manag. 2017 Apr;7(2):119-145. doi: 10.2217/nmt-2016-0060. Epub 2017 May 23.
Abstract
Alzheimer's disease and related dementias (ADRD) can cause sleep and behavioral problems that are problematic for ADRD patients and their family caregivers. Light therapy has shown promise as a nonpharmacological treatment, and preliminary studies demonstrate that timed light exposure can consolidate and improve nighttime sleep efficiency, increase daytime wakefulness and reduce evening agitation without the adverse effects of pharmacological solutions. Compliance with light treatment and the accurate measurement of light exposures during treatment, however, have presented barriers for the adoption of light therapy for ADRD. Recent research showing that the circadian system is maximally sensitive to short-wavelength light opens the way for the potential application of lower, more-targeted light intensities to maximize compliance and individualize light dose/timing in therapeutic settings.
摘要
阿尔茨海默病及相关痴呆症（ADRD）会引发睡眠和行为问题，这对ADRD患者及其家庭护理人员来说都是难题。光照疗法已显示出作为一种非药物治疗方法的前景，初步研究表明，定时光照可以巩固并提高夜间睡眠效率，增加白天的清醒度，并减少夜间烦躁，且没有药物治疗方案的副作用。然而，光照治疗的依从性以及治疗期间光照暴露的准确测量，一直是ADRD患者采用光照疗法的障碍。最近的研究表明，昼夜节律系统对短波长光最为敏感，这为在治疗环境中应用更低、更具针对性的光照强度以提高依从性并实现光照剂量/时间的个性化开辟了道路。
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