Yoo Andrea S, Wise Adina, Ortega Roberto A, Raymond Deborah, Plitnick Barbara, Brons Jennifer, Liang Judy, Bressman Susan B, Yang Mengxi, Pedler David, Figueiro Mariana G, Saunders-Pullman Rachel
Department of Neurology, Icahn School of Medicine at Mount Sinai and Mount Sinai Beth Israel, 10 Union Square East, New York, NY, USA.
Department of Neurology, Icahn School of Medicine at Mount Sinai and Mount Sinai Beth Israel, 10 Union Square East, New York, NY, USA; Medical Scientist Training Program, Albert Einstein College of Medicine, Bronx, NY, USA.
Parkinsonism Relat Disord. 2024 Dec;129:107149. doi: 10.1016/j.parkreldis.2024.107149. Epub 2024 Sep 20.
Sleep disturbances in Parkinson's disease (PD) are common and often adversely affect quality of life. Light therapy has benefited sleep quality and mood outcomes in various populations but results to date with conventional light therapy boxes in PD patients have been mixed. We hypothesized that a passive lighting intervention, applied in the morning and designed to maximally affect the circadian system, would improve measures of sleep and mood in PD patients.
In this single-arm, within-subjects intervention study, baseline objective sleep (actigraphy), subjective sleep quality (questionnaires), and subjective mood (questionnaires) data were collected for 1 week. Lighting was then administered to participants via table/floor lamps installed in the home or via personal light therapy glasses for 2 h in the morning, 7 days per week, over the following 4-week period. Post-intervention data for the same outcomes were collected during the final week of the intervention period.
Among 20 participants (12 women, 8 men; mean [SD] age 72.1 [9.5] years, disease duration 9.0 [5.2] years), objective sleep duration increased significantly by 28.5 min (p = 0.029) and objective sleep time increased significantly by 19.9 min (p = 0.026).
Passive and easily administered lighting interventions for improving sleep in PD patients hold promise as a treatment for mitigating symptoms and improving quality of life in PD.
帕金森病（PD）患者的睡眠障碍很常见，且常常对生活质量产生不利影响。光疗法已使不同人群的睡眠质量和情绪状况得到改善，但迄今为止，传统光疗箱用于PD患者的效果参差不齐。我们推测，一种在早晨应用且旨在最大程度影响昼夜节律系统的被动照明干预措施，将改善PD患者的睡眠和情绪指标。
在这项单臂、受试者内干预研究中，收集了1周的基线客观睡眠（活动记录仪）、主观睡眠质量（问卷调查）和主观情绪（问卷调查）数据。随后，在接下来的4周时间里，通过安装在家里的台灯/落地灯或个人光疗眼镜，每周7天，每天早晨为参与者提供2小时的光照。在干预期的最后一周收集相同指标的干预后数据。
在20名参与者（12名女性，8名男性；平均[标准差]年龄72.1[9.5]岁，病程9.0[5.2]年）中，客观睡眠时间显著增加了28.5分钟（p = 0.029），客观睡眠时长显著增加了19.9分钟（p = 0.026）。
用于改善PD患者睡眠的被动且易于实施的照明干预措施有望成为减轻PD症状和改善生活质量的一种治疗方法。
