Filanovskaia L I, Blinov M N, Togo A V, Klubovskaia N I, Burmistrova E V
Vopr Med Khim. 1988 Nov-Dec;34(6):71-6.
Activities of the enzymes, responsible for degradation of purine nucleotides in leukocytes, were distinctly dissimilar in M1, M2, M4 and M6 variants of acute non-lymphoblastic leukosis studied in 34 patients. Differentiation of leukemic cells was shown to be due to alterations in activity of adenosine deaminase and purine nucleoside phosphorylase, which were oppositely directed as compared with those observed in lymphoblasts under conditions of acute lymphoblast leukosis. Evaluation of activities of adenosine deaminase, purine nucleoside phosphorylase and 5'-nucleotidase is of importance for characteristics of individual variants of acute non-lymphoblastic leukosis and for elucidation of the state of leukemic clone differentiation, which may affect the efficiency of the therapeutic measures used.
在对34例患者进行研究的急性非淋巴细胞白血病的M1、M2、M4和M6变种中，负责白细胞中嘌呤核苷酸降解的酶的活性明显不同。结果表明，白血病细胞的分化是由于腺苷脱氨酶和嘌呤核苷磷酸化酶活性的改变，与急性淋巴细胞白血病情况下淋巴细胞母细胞中观察到的活性变化方向相反。评估腺苷脱氨酶、嘌呤核苷磷酸化酶和5'-核苷酸酶的活性对于急性非淋巴细胞白血病个体变种的特征描述以及阐明白血病克隆分化状态很重要，这可能会影响所采用治疗措施的效果。
