Khoshnam Seyed Esmaeil, Winlow William, Farzaneh Maryam
Department of Physiology, Faculty of Medicine, Physiology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; Dipartimento di Biologia, Università degli Studi di Napoli, Federico II, Napoli, Italy and Institute of Ageing and Chronic Diseases, University of Liverpool, Liverpool, UK; and Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
J Neuropathol Exp Neurol. 2017 Jul 1;76(7):548-561. doi: 10.1093/jnen/nlx036.
Immunity and inflammation are important parameters of the pathophysiology of stroke, a destructive illness that is the second most common cause of death worldwide. Following ischemic stroke, neuroinflammation plays a critical role in neurodegeneration and brain injury. MicroRNAs (miRNAs) are a class of endogenously expressed, noncoding RNA molecules that function to inhibit mRNA translation. Recent studies demonstrate that miRNAs are key regulators of inflammatory processes contributing to ischemic stroke injuries. Several miRNAs, and their target genes, have been shown to play a critical role in the innate inflammatory responses mediated by immune cells. The capacity of miRNAs to regulate several target genes demonstrates their exceptional importance in neuroinflammatory therapeutics following ischemic stroke. In this review, we focus on the miRNAs associated with ischemic neuroinflammation and describe the potential of miRNAs as biomarkers of neuroinflammation and promising therapeutic agents for modulation of deleterious inflammatory responses following ischemic stroke.
免疫和炎症是中风病理生理学的重要参数，中风是一种具有破坏性的疾病，是全球第二大常见死因。缺血性中风后，神经炎症在神经退行性变和脑损伤中起关键作用。微小RNA（miRNA）是一类内源性表达的非编码RNA分子，其功能是抑制mRNA翻译。最近的研究表明，miRNA是导致缺血性中风损伤的炎症过程的关键调节因子。几种miRNA及其靶基因已被证明在免疫细胞介导的先天性炎症反应中起关键作用。miRNA调节多个靶基因的能力表明它们在缺血性中风后的神经炎症治疗中具有特殊重要性。在这篇综述中，我们聚焦于与缺血性神经炎症相关的miRNA，并描述miRNA作为神经炎症生物标志物的潜力以及作为调节缺血性中风后有害炎症反应的有前景的治疗药物的潜力。
