Division of Behavioral Medicine and Clinical Psychology Cincinnati Children's Hospital Medical Center.
Office of Behavioral and Social Science Research, Office of the Director, NIH.
J Pediatr Psychol. 2018 Jan 1;43(1):83-93. doi: 10.1093/jpepsy/jsx084.
This study tested hypotheses drawn from a risk model positing that psychosocial risk plus disease-related and treatment factors contribute to bulimic symptoms in youth with type 1 diabetes (T1D) transitioning to an insulin pump. The goal of this study was to examine whether disease-related factors, particularly disease- and treatment-based disruption in hunger and satiety, contribute to report of bulimic symptoms in youth with T1D after accounting for psychosocial risk factors.
43 youth (ages 10-17, 54% female) with established T1D were recruited before transition from multiple daily injections to insulin-pump therapy from three tertiary pediatric diabetes centers. Participants completed measures of bulimic symptoms, depressive symptoms dietary restraint, and the Diabetes Treatment and Satiety Scale, a diabetes-specific questionnaire assessing hunger and satiety cues and eating behavior in response to blood glucose levels and treatment.
Hierarchical multiple regression was used to assess contributions of psychosocial and disease-based risk to report of bulimic symptoms. After assessing the contributions of body mass index, body image dissatisfaction, and dietary restraint, a significant 2-way interaction emerged between depression and diabetes-related uncontrollable hunger related to bulimic symptoms (β = 1.82, p < .01).
In addition to psychosocial risk, disease- and treatment-based hunger and satiety dysregulation appear to be important factors contributing to report of bulimic symptoms in youth with T1D. These preliminary findings have significant treatment implications for bulimic symptoms in youth with T1D.
本研究检验了一个风险模型提出的假设,即心理社会风险加上与疾病相关的因素和治疗因素共同导致 1 型糖尿病(T1D)青少年在向胰岛素泵过渡时出现贪食症状。本研究的目的是检验在考虑到心理社会风险因素后,与疾病相关的因素,特别是与疾病和治疗相关的饥饿和饱腹感紊乱,是否会导致 T1D 青少年报告贪食症状。
从三个儿科糖尿病三级中心招募了 43 名年龄在 10-17 岁之间(54%为女性)、已确诊 T1D 的青少年,这些青少年即将从多次每日注射改为胰岛素泵治疗。参与者完成了贪食症状、抑郁症状、饮食限制以及糖尿病治疗和饱腹感量表的测量,这是一种糖尿病特异性问卷,评估了饥饿和饱腹感线索以及根据血糖水平和治疗进行的进食行为。
采用分层多元回归分析评估心理社会和基于疾病的风险对贪食症状报告的贡献。在评估了体重指数、身体形象不满和饮食限制的贡献后,抑郁和与糖尿病相关的不可控饥饿之间出现了显著的 2 路交互作用,与贪食症状相关(β=1.82,p<0.01)。
除了心理社会风险,与疾病和治疗相关的饥饿和饱腹感失调似乎是导致 T1D 青少年报告贪食症状的重要因素。这些初步发现对 T1D 青少年的贪食症状治疗具有重要意义。