Roxburgh Amanda, Darke Shane, Salmon Allison M, Dobbins Timothy, Jauncey Marianne
National Drug and Alcohol Research Centre (NDARC), University of New South Wales, Sydney, NSW 2052, Australia.
National Drug and Alcohol Research Centre (NDARC), University of New South Wales, Sydney, NSW 2052, Australia.
Drug Alcohol Depend. 2017 Jul 1;176:126-132. doi: 10.1016/j.drugalcdep.2017.02.027. Epub 2017 May 17.
Pharmaceutical opioid overdose rates have increased in recent years. The current study aimed to compare rates per 1000 injections of non-fatal overdose after heroin or oxycodone injection, and their comparative clinical severity.
Analysis of prospectively collected data from the Sydney Medically Supervised Injecting Centre (MSIC). Severity of overdose was measured using the Glasgow Coma Scale, oxygen saturation levels, and the administration of naloxone.
Heroin overdoses occurred at three times the rate of oxycodone overdoses (12.7 v 4.1 per 1000 injections). Heroin overdoses appeared to be more severe than oxycodone overdoses, with higher levels of compromised consciousness (31 v 18%) and severe respiratory depression (67 v 48%), but there were no differences in naloxone doses (20 v 17%). Concurrent use of other depressants at the time of overdose was also associated with compromised consciousness, and the need for naloxone.
Heroin overdoses occurred at a greater rate than oxycodone overdoses, and had more severe clinical indicators.
近年来，药用阿片类药物过量使用率有所上升。本研究旨在比较海洛因或羟考酮注射后每1000次注射的非致命过量使用率及其相对临床严重程度。
对悉尼医学监督注射中心（MSIC）前瞻性收集的数据进行分析。使用格拉斯哥昏迷量表、血氧饱和度水平和纳洛酮的使用情况来衡量过量的严重程度。
海洛因过量发生率是羟考酮过量发生率的三倍（每1000次注射中分别为12.7次和4.1次）。海洛因过量似乎比羟考酮过量更严重，意识受损水平更高（31%对18%），严重呼吸抑制发生率更高（67%对48%），但纳洛酮剂量无差异（20对17）。过量时同时使用其他抑制剂也与意识受损和需要使用纳洛酮有关。
海洛因过量发生率高于羟考酮过量，且具有更严重的临床指标。
