电催化 2'-氨基苯乙酮的 C-H/N-H 偶联反应合成色满酮。
Electrocatalytic C-H/N-H Coupling of 2'-Aminoacetophenones for the Synthesis of Isatins.
机构信息
Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Soft Matter Chemistry and Department of Chemistry & Collaborative Innovation Center of Suzhou Nano Science and Technology and ‡CAS Key Laboratory of Microscale Magnetic Resonance, Department of Modern Physics, University of Science and Technology of China , Hefei, Anhui 230026, P. R. China.
出版信息
J Org Chem. 2017 Jun 16;82(12):6434-6440. doi: 10.1021/acs.joc.7b00635. Epub 2017 Jun 2.
2'-Aminoacetophenones undergo a C(sp)-H oxidation followed by intramolecular C-N bond formation by virtue of a simple electrochemical oxidation in the presence of n-BuNI, providing various isatins with moderate to good yields. The reaction intermediates were detected, and a radical-based pathway was proposed.
2'-氨基苯乙酮在正丁基碘化铵存在下通过简单的电化学氧化作用经历 C(sp3)-H 氧化，然后进行分子内 C-N 键形成，以中等至良好的收率提供各种色满酮。检测到了反应中间体，并提出了基于自由基的反应途径。
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