Meng Shujuan, Zhou Hecheng, Feng Ziyang, Xu Zihao, Tang Ying, Li Peiyao, Wu Minghua
Hunan Provincial Tumor Hospital and the Affiliated Tumor Hospital of Xiangya Medical School, Central South University, Changsha, 410013, Hunan, China.
The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, 410008, China.
Mol Cancer. 2017 May 23;16(1):94. doi: 10.1186/s12943-017-0663-2.
Circular RNAs, a novel class of endogenous noncoding RNAs, are characterized by their covalently closed loop structures without a 5' cap or a 3' Poly A tail. Although the mechanisms of circular RNAs' generation and function are not fully clear, recent research has shown that circular RNAs may function as potential molecular markers for disease diagnosis and treatment and play an important role in the initiation and progression of human diseases, especially in tumours. This review summarizes some information about categories, biogenesis, functions at the molecular level, properties of circular RNAs and the possibility of circular RNAs as biomarkers in cancers.
环状RNA是一类新型的内源性非编码RNA，其特征在于具有共价闭合的环状结构，没有5'帽或3'聚腺苷尾。尽管环状RNA的生成和功能机制尚不完全清楚，但最近的研究表明，环状RNA可能作为疾病诊断和治疗的潜在分子标志物，并在人类疾病尤其是肿瘤的发生和发展中发挥重要作用。本文综述了有关环状RNA的类别、生物发生、分子水平功能、特性以及环状RNA作为癌症生物标志物的可能性等方面的一些信息。
