Rady Islam, Siddiqui Imtiaz A, Rady Mohamad, Mukhtar Hasan
School of Medicine and Public Health, Department of Dermatology, University of Wisconsin-Madison, WI 53706, USA; Department of Zoology, Faculty of Science, Al-Azhar University, Cairo, Egypt.
School of Medicine and Public Health, Department of Dermatology, University of Wisconsin-Madison, WI 53706, USA.
Cancer Lett. 2017 Aug 28;402:16-31. doi: 10.1016/j.canlet.2017.05.010. Epub 2017 May 20.
Melittin (MEL), a major peptide component of bee venom, is an attractive candidate for cancer therapy. This agent has shown a variety of anti-cancer effects in preclinical cell culture and animal model systems. Despite a convincing efficacy data against variety of cancers, its applicability to humans has met with challenges due to several issues including its non-specific cytotoxicity, degradation and hemolytic activity. Several optimization approaches including utilization of nanoparticle based delivery of MEL have been utilized to circumvent the issues. Here, we summarize the current understanding of the anticancer effects of bee venom and MEL on different kinds of cancers. Further, we also present the available information for the possible mechanism of action of bee venom and/or MEL.
蜂毒肽（MEL）是蜂毒的主要肽成分，是一种有吸引力的癌症治疗候选物。该药物在临床前细胞培养和动物模型系统中已显示出多种抗癌作用。尽管有令人信服的针对多种癌症的疗效数据，但由于包括非特异性细胞毒性、降解和溶血活性等几个问题，其在人类中的应用面临挑战。已经采用了几种优化方法，包括利用基于纳米颗粒的蜂毒肽递送，以规避这些问题。在这里，我们总结了目前对蜂毒和蜂毒肽对不同类型癌症的抗癌作用的理解。此外，我们还介绍了关于蜂毒和/或蜂毒肽可能的作用机制的现有信息。
