Department of Molecular Biosciences, Institute for Cellular and Molecular Biology, LaMontagne Center for Infectious Disease, The University of Texas at Austin, Austin, Texas, USA.
Department of Molecular Biosciences, Institute for Cellular and Molecular Biology, LaMontagne Center for Infectious Disease, The University of Texas at Austin, Austin, Texas, USA
mBio. 2017 May 23;8(3):e00675-17. doi: 10.1128/mBio.00675-17.
Chronic polymicrobial infections are associated with increased virulence compared to monospecies infections. However, our understanding of microbial dynamics during polymicrobial infection is limited. A recent study by Limoli and colleagues (D. H. Limoli, G. B. Whitfield, T. Kitao, M. L. Ivey, M. R. Davis, Jr., et al., mBio 8:e00186-17, 2017, https://doi.org/10.1128/mBio.00186-17) provides insight into a mechanism that may contribute to the coexistence of and in the cystic fibrosis (CF) lung. CF lung infections have frequently been used to investigate microbial interactions due to both the complex polymicrobial community and chronic nature of these infections. The hypothesis of Limoli et al. is that the conversion of to its mucoidy phenotype during chronic CF infection promotes coexistence by diminishing its ability to kill Highlighting a new facet of microbial interaction between two species that are traditionally thought of as competitors, this study provides a platform for studying community assembly in a relevant infection setting.
慢性多微生物感染与单物种感染相比，其毒力增加。然而，我们对多微生物感染期间微生物动态的理解是有限的。最近 Limoli 等人的一项研究（D. H. Limoli、G. B. Whitfield、T. Kitao、M. L. Ivey、M. R. Davis, Jr. 等人，mBio 8:e00186-17, 2017, https://doi.org/10.1128/mBio.00186-17）提供了一个可能有助于 和 在囊性纤维化（CF）肺中共存的机制的见解。由于 CF 肺部感染的复杂多微生物群落和慢性性质，这些感染经常被用于研究微生物相互作用。Limoli 等人的假设是，在慢性 CF 感染过程中， 向粘液表型的转化通过降低其杀死 的能力，促进了共存。这项研究强调了两种传统上被认为是竞争者的物种之间微生物相互作用的一个新方面，为在相关感染环境中研究群落组装提供了一个平台。
