Department of Chinese Medicine, China Medical University Hospital, Taichung, Taiwan.
School of Chinese Medicine, China Medical University, Taichung, Taiwan.
Sci Rep. 2020 Jun 19;10(1):10008. doi: 10.1038/s41598-020-66707-1.
Both inflammation and infection are associated with the development of irritable bowel syndrome (IBS) and chronic obstructive pulmonary disease (COPD). The purpose of this study is to further elucidate the association between IBS and COPD through a retrospective cohort study. We enrolled IBS patients diagnosed between 2000 and 2011 with follow-up for at least one year. The non-IBS patients as comparison group were selected with 1:3 matching by propensity score. Statistical analysis was utilized to assess the differences in characteristic distribution, and to compare the cumulative incidence of COPD between the IBS and non-IBS cohorts. We selected 14,021 IBS patients and 42,068 non-IBS patients for comparison. The IBS patients exhibited a significant risk to develop COPD compared with non-IBS patients. Additionally, the cumulative incidence rate of COPD in the IBS cohort increased significantly during the follow-up period of more than ten years, compared to the non-IBS cohort, based on the Kaplan-Meier analysis. The risk of COPD was also significantly decreased in those patients with more than eighteen IBS-related clinical visits. This retrospective cohort study demonstrates the significantly increased risk of COPD in patients with IBS. Therefore, early inspection and prevention of COPD is essential for patients with IBS.
炎症和感染都与肠易激综合征（IBS）和慢性阻塞性肺疾病（COPD）的发展有关。本研究旨在通过回顾性队列研究进一步阐明 IBS 和 COPD 之间的关联。我们招募了 2000 年至 2011 年间诊断为 IBS 且随访至少一年的 IBS 患者。非 IBS 患者作为对照组，按照倾向评分匹配 1:3。统计分析用于评估特征分布的差异，并比较 IBS 和非 IBS 队列中 COPD 的累积发病率。我们选择了 14021 名 IBS 患者和 42068 名非 IBS 患者进行比较。与非 IBS 患者相比，IBS 患者发生 COPD 的风险显著增加。此外，基于 Kaplan-Meier 分析，IBS 队列在超过十年的随访期间，COPD 的累积发生率显著增加，而非 IBS 队列则没有。IBS 相关临床就诊次数超过 18 次的患者，COPD 的风险也显著降低。这项回顾性队列研究表明，IBS 患者患 COPD 的风险显著增加。因此，对于 IBS 患者，早期检查和预防 COPD 至关重要。
