Suppr超能文献

儿童贲门失弛缓症行赫勒肌切开术和球囊扩张术的长期疗效

Long-term outcomes of Heller's myotomy and balloon dilatation in childhood achalasia.

作者信息

Saliakellis Efstratios, Thapar Nikhil, Roebuck Derek, Cristofori Fernanda, Cross Kate, Kiely Edward, Curry Joseph, Lindley Keith, Borrelli Osvaldo

机构信息

Neurogastroenterology and Motility Unit, Department of Gastroenterology,, Great Ormond Street Hospital NHS Foundation Trust, London, UK.

Stem Cells and Regenerative Medicine, UCL Great Ormond Street Institute of Child Health, London, UK.

出版信息

Eur J Pediatr. 2017 Jul;176(7):899-907. doi: 10.1007/s00431-017-2924-x. Epub 2017 May 23.

Abstract

UNLABELLED

Achalasia is a rare esophageal motility disorder: its optimal treatment in children is still a matter of debate. Records of children treated for achalasia, over an 18-year period, were reviewed.Forty-eight children (median age at diagnosis 10 years; range 3-17 years) were identified. Twenty-eight patients were initially treated with Heller's myotomy (HM) and 20 with balloon dilatation (BD). At last follow-up (median 3 years; range 1-5.5 years), 43.8% (21/48) of children were symptom free. The number of asymptomatic children was significantly higher among those treated initially with HM compared to BD (HM 15/28, 53.6% BD 6/20, 30%, p < 0.05). All children who underwent BD required HM due to symptom recurrence. The median (range) total number of procedures was significantly higher in the BD group (BD 3 (1-7); HM 1 (1-5); p < 0.05) with a shorter time to the second intervention (BD 14 months, 95%CI 4-24; HM 58 months, 95%CI 38-79; p < 0.05). Of 108 procedures, esophageal perforation occurred in two children after HM (two out of 48 HM procedures in total, 4%) and one child after BD (1/60, 1.7%).

CONCLUSION

Less than half of children with achalasia are symptom free after initial treatment with either BD or HM. HM, however, when performed as first procedure, provided longer symptom-free period and reduced need for subsequent intervention. What is Known: • Balloon dilatation (BD) and Heller's myotomy (HM) are safe and effective treatment options for achalasia. • Controversy, however, exists regarding the most effective initial therapeutic approach. What is New: • HM with or without fundoplication may represent the initial therapeutic approach of choice. • Initial BD may negatively affect the outcome of a subsequent HM.

摘要

未标注

贲门失弛缓症是一种罕见的食管动力障碍性疾病:其在儿童中的最佳治疗方法仍存在争议。回顾了18年间接受贲门失弛缓症治疗的儿童记录。共确定了48名儿童(诊断时的中位年龄为10岁;范围为3至17岁)。28例患者最初接受了赫勒肌切开术(HM)治疗,20例接受了球囊扩张术(BD)治疗。在最后一次随访时(中位时间为3年;范围为1至5.5年),43.8%(21/48)的儿童症状消失。与接受BD治疗的儿童相比,最初接受HM治疗的儿童中无症状儿童的数量显著更高(HM组15/28,53.6%;BD组6/20,30%,p<0.05)。所有接受BD治疗的儿童由于症状复发均需要进行HM治疗。BD组的手术总次数中位数(范围)显著高于HM组(BD组3(1至7);HM组1(1至5);p<0.05),且第二次干预的时间更短(BD组14个月,95%CI为4至24;HM组58个月,95%CI为38至79;p<0.05)。在108次手术中,2名接受HM治疗的儿童发生了食管穿孔(HM手术共48次,2例,4%),1名接受BD治疗的儿童发生了食管穿孔(1/60,1.7%)。

结论

无论是BD还是HM,在对贲门失弛缓症儿童进行初始治疗后,不到一半的儿童症状消失。然而,当首次进行HM手术时,其无症状期更长,且减少了后续干预的需求。已知信息:• 球囊扩张术(BD)和赫勒肌切开术(HM)是治疗贲门失弛缓症的安全有效选择。• 然而,关于最有效的初始治疗方法存在争议。新发现:• 有或没有胃底折叠术的HM可能是首选的初始治疗方法。• 初始BD可能会对后续HM的结果产生负面影响。

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验