School of Chemistry, Trinity College Dublin, Dublin D2, Ireland.
Nat Commun. 2017 May 24;8:15655. doi: 10.1038/ncomms15655.
-to- acyl transfer is a high-yielding chemoselective process for amide bond formation. It is widely utilized by chemists for synthetic applications, including peptide and protein synthesis, chemical modification of proteins, protein-protein ligation and the development of probes and molecular machines. Recent advances in our understanding of -to- acyl transfer processes in biology and innovations in methodology for thioester formation and desulfurization, together with an extension of the size of cyclic transition states, have expanded the boundaries of this process well beyond peptide ligation. As the field develops, this chemistry will play a central role in our molecular understanding of Biology.
酰基转移是酰胺键形成的高产率、选择性化学反应。化学家广泛地将其应用于合成领域，包括肽和蛋白质合成、蛋白质的化学修饰、蛋白质-蛋白质连接以及探针和分子机器的开发。我们对生物体内酰基转移过程的理解的最新进展，以及硫酯形成和脱硫方法的创新，加上环状过渡态大小的扩展，已经使该反应的应用范围远远超出了肽键的连接。随着该领域的发展，该化学将在我们对生物学的分子理解中发挥核心作用。
