Rogers Laura Q, Courneya Kerry S, Oster Robert A, Anton Philip M, Robbs Randall S, Forero Andres, McAuley Edward
1Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL; 2Faculty of Physical Education and Recreation, University of Alberta, Edmonton, Alberta, CANADA; 3Department of Medicine, University of Alabama at Birmingham, Birmingham, AL; 4Department of Kinesiology, Southern Illinois University Carbondale, Carbondale, IL; 5Statistics and Research Informatics Core, Center for Clinical Research, Southern Illinois University School of Medicine, Springfield, IL; and 6Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, IL.
Med Sci Sports Exerc. 2017 Oct;49(10):2009-2015. doi: 10.1249/MSS.0000000000001327.
Data from large randomized controlled trials confirming sleep quality improvements with aerobic physical activity have heretofore been lacking for post-primary treatment breast cancer survivors. Our primary purpose for this report was to determine the effects of a physical activity behavior change intervention, previously reported to significantly increase physical activity behavior, on sleep quality in post-primary treatment breast cancer survivors.
Post-primary treatment breast cancer survivors (n = 222) were randomized to a 3-month physical activity behavior change intervention (Better Exercise Adherence after Treatment for Cancer [BEAT Cancer]) or usual care. Self-report (Pittsburgh Sleep Quality Index [PSQI]) and actigraphy (latency and efficiency) sleep outcomes were measured at baseline, 3 months (M3), and 6 months (M6).
After adjusting for covariates, BEAT Cancer significantly improved PSQI global sleep quality when compared with usual care at M3 (mean between-group difference [M] = -1.4, 95% confidence interval [CI] = -2.1 to -0.7, P < 0.001) and M6 (M = -1.0, 95% CI = -1.7 to -0.2, P = 0.01). BEAT Cancer improved several PSQI subscales at M3 (sleep quality M = -0.3, 95% CI = -0.4 to -0.1, P = 0.002; sleep disturbances M = -0.2, 95% CI = -0.3 to -0.03, P = 0.016; daytime dysfunction M = -0.2, 95% CI = -0.4 to -0.02, P = 0.027) but not M6. A nonsignificant increase in percent of participants classified as good sleepers occurred. No significant between-group difference was noted for accelerometer latency or efficiency.
A physical activity intervention significantly reduced perceived global sleep dysfunction at 3 and 6 months, primarily because of improvements in sleep quality aspects not detected with accelerometer.
对于接受过初始治疗的乳腺癌幸存者而言，此前缺乏来自大型随机对照试验的数据来证实有氧运动能改善睡眠质量。本报告的主要目的是确定一项体育活动行为改变干预措施（此前报告显示该措施能显著增加体育活动行为）对接受过初始治疗的乳腺癌幸存者睡眠质量的影响。
将接受过初始治疗的乳腺癌幸存者（n = 222）随机分为两组，一组接受为期3个月的体育活动行为改变干预（癌症治疗后更好地坚持锻炼[BEAT癌症]），另一组接受常规护理。在基线、3个月（M3）和6个月（M6）时测量自我报告（匹兹堡睡眠质量指数[PSQI]）和活动记录仪（入睡潜伏期和睡眠效率）的睡眠结果。
在对协变量进行调整后，与常规护理相比，BEAT癌症干预在M3时显著改善了PSQI整体睡眠质量（组间平均差异[M] = -1.4，95%置信区间[CI] = -2.1至-0.7，P < 0.001），在M6时也有显著改善（M = -1.0，95% CI = -1.7至-0.2，P = 0.01）。BEAT癌症干预在M3时改善了几个PSQI子量表（睡眠质量M = -0.3，95% CI = -0.4至-0.1，P = 0.002；睡眠障碍M = -0.2，95% CI = -0.3至-0.03，P = 0.016；日间功能障碍M = -0.2，95% CI = -0.4至-0.02，P = 0.027），但在M6时没有。被归类为睡眠良好的参与者比例有不显著的增加。在加速度计测量的入睡潜伏期或睡眠效率方面，两组之间没有显著差异。
一项体育活动干预在3个月和6个月时显著降低了感知到的整体睡眠功能障碍，这主要是由于在加速度计未检测到的睡眠质量方面有所改善。
