体育活动干预的益处会在干预结束后的数月持续存在：针对乳腺癌幸存者的随机试验
Physical activity intervention benefits persist months post-intervention: randomized trial in breast cancer survivors.
作者信息
Rogers Laura Q, Courneya Kerry S, Oster Robert A, Anton Philip M, Phillips Siobhan, Ehlers Diane K, McAuley Edward
机构信息
Department of Medicine, School of Medicine, University of Alabama at Birmingham, 1720 2nd Ave S, MT 614, AL, 35294-4410, Birmingham, USA.
Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, AB, Canada.
出版信息
J Cancer Surviv. 2023 Dec;17(6):1834-1846. doi: 10.1007/s11764-022-01329-2. Epub 2023 Feb 1.
PURPOSE
Determine durable effects of the 3-month Better Exercise Adherence after Treatment for Cancer (BEAT Cancer) physical activity (PA) behavior change intervention 12 months post-baseline (i.e., 9 months after intervention completion).
METHODS
This 2-arm multicenter trial randomized 222 post-primary treatment breast cancer survivors to BEAT Cancer (individualized exercise and group education) vs. usual care (written materials). Assessments occurred at baseline, 3, 6, and 12 months, with the 12 months assessment reported here. Measures included PA (accelerometer, self-report), cardiorespiratory fitness, muscle strength, body mass index, Functional Assessment of Cancer Therapy (FACT), SF-36, fatigue, depression, anxiety, satisfaction with life, Pittsburgh Sleep Quality Index (PSQI), lower extremity joint dysfunction, and perceived memory.
RESULTS
Adjusted linear mixed-model analyses demonstrated statistically significant month 12 between-group differences favoring BEAT Cancer for weekly minutes of moderate-to-vigorous self-report PA (mean between-group difference (M) = 44; 95% confidence interval (CI) = 12 to 76; p = .001), fitness (M = 1.5 ml/kg/min; CI = 0.4 to 2.6; p = .01), FACT-General (M = 3.5; CI = 0.7 to 6.3; p = .014), FACT-Breast (M = 3.6; CI = 0.1 to 7.1; p = .044), social well-being (M = 1.3; CI = 0.1 to 2.5; p = .037), functional well-being (M = 1.2; CI = 0.2 to 2.3; p = .023), SF-36 vitality (M = 6.1; CI = 1.4 to 10.8; p = .011), fatigue (M = - 0.7; CI = - 1.1 to - 0.2; p = .004), satisfaction with life (M = 1.9; CI = 0.3 to 3.5; p = .019), sleep duration (M = - 0.2; CI = - 0.4 to - 0.03, p = .028), and memory (M = 1.1; CI = 0.2 to 2.1; p = .024).
CONCLUSIONS
A 3-month PA intervention resulted in statistically significant and clinically important benefits compared to usual care at 12 months.
IMPLICATIONS FOR CANCER SURVIVORS
Three months of individualized and group PA counseling causes benefits detectable 9 months later.
TRIAL REGISTRATION
ClinicalTrials.gov NCT00929617 ( https://clinicaltrials.gov/ct2/show/NCT00929617 ; registered June 29, 2009).
目的
确定癌症治疗后3个月的更佳运动依从性（BEAT Cancer）身体活动（PA）行为改变干预在基线后12个月（即干预完成后9个月）的持久效果。
方法
这项双臂多中心试验将222名原发性治疗后的乳腺癌幸存者随机分为BEAT Cancer组（个性化运动和小组教育）和常规护理组（书面材料）。在基线、3个月、6个月和12个月进行评估，此处报告的是12个月的评估结果。测量指标包括PA（加速度计、自我报告）、心肺适能、肌肉力量、体重指数、癌症治疗功能评估（FACT）、SF-36、疲劳、抑郁、焦虑、生活满意度、匹兹堡睡眠质量指数（PSQI）、下肢关节功能障碍和感知记忆。
结果
调整后的线性混合模型分析显示，在第12个月，两组之间存在统计学上的显著差异，有利于BEAT Cancer组的指标包括：中度至剧烈自我报告PA的每周分钟数（组间平均差异（M）=44；95%置信区间（CI）=12至76；p = 0.001）、适能（M = 1.5 ml/kg/min；CI = 0.4至2.6；p = 0.01）、FACT-通用版（M = 3.5；CI = 0.7至6.3；p = 0.014）、FACT-乳腺癌版（M = 3.6；CI = 0.1至7.1；p = 0.044）、社会幸福感（M = 1.3；CI = 0.1至2.5；p = 0.037）、功能幸福感（M = 1.2；CI = 0.2至2.3；p = 0.023）、SF-36活力（M = 6.1；CI = 1.4至10.8；p = 0.011）、疲劳（M = -0.7；CI = -1.1至-0.2；p = 0.004）、生活满意度（M = 1.9；CI = 0.3至3.5；p = 0.019）、睡眠时间（M = -0.2；CI = -0.4至-0.03，p = 0.028）和记忆（M = 1.1；CI = 0.2至2.1；p = 0.024）。
结论
与常规护理相比，为期3个月的PA干预在12个月时产生了统计学上显著且具有临床意义的益处。
对癌症幸存者的启示
三个月的个性化和小组PA咨询在9个月后仍能产生可检测到的益处。
试验注册
ClinicalTrials.gov NCT00929617（https://clinicaltrials.gov/ct2/show/NCT00929617；2009年6月29日注册）。
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