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5'-核苷酸酶在reeler突变小鼠中的组织化学定位

Histochemical localization of 5'-nucleotidase in the reeler mutant mouse.

作者信息

Eisenman L M

机构信息

Department of Anatomy, Jefferson Medical College, Philadelphia, PA 19107.

出版信息

Neurosci Lett. 1988 Nov 22;94(1-2):70-5. doi: 10.1016/0304-3940(88)90272-8.

DOI:10.1016/0304-3940(88)90272-8
PMID:2853855
Abstract

In the normal mouse cerebellum, 5'-nucleotidase localization exhibits a parasagittal organization with bands of positive and negative staining within the molecular layer. The reeler cerebellum, which possesses an abnormal cytoarchitecture with numerous ectopically located Purkinje cells, was stained histochemically for the presence of 5'-nucleotidase. The resulting staining pattern suggests that 5'-nucleotidase is found in association with areas containing subpopulations of Purkinje cells, independent of whether they are in normal or ectopic positions.

摘要

在正常小鼠小脑中,5'-核苷酸酶的定位呈现出一种矢状旁组织,在分子层内有阳性和阴性染色带。reeler小鼠的小脑具有异常的细胞结构,有许多异位定位的浦肯野细胞,对其进行了5'-核苷酸酶存在情况的组织化学染色。所得的染色模式表明,5'-核苷酸酶与含有浦肯野细胞亚群的区域相关,而不论它们是处于正常位置还是异位位置。

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