Histochemical localization of 5'-nucleotidase in the reeler mutant mouse.

In the normal mouse cerebellum, 5'-nucleotidase localization exhibits a parasagittal organization with bands of positive and negative staining within the molecular layer. The reeler cerebellum, which possesses an abnormal cytoarchitecture with numerous ectopically located Purkinje cells, was stained histochemically for the presence of 5'-nucleotidase. The resulting staining pattern suggests that 5'-nucleotidase is found in association with areas containing subpopulations of Purkinje cells, independent of whether they are in normal or ectopic positions.