Hess D T, Hess A
Brain Res. 1986 Sep;394(1):93-100. doi: 10.1016/0165-3806(86)90085-4.
The molecular layer of the cerebellar cortex contains high levels of the enzyme 5'-nucleotidase (EC 3.1.3.5), localized predominantly to Bergmann glia. In the present study, histochemical methods have been employed to examine the distribution of cerebellar 5'-nucleotidase in mice of two separate mutant strains in which Purkinje cells are eliminated selectively. In homozygous 'Purkinje cell degeneration' (pcd) and 'nervous' (nr) mice, molecular layer 5'-nucleotidase is greatly reduced and residual enzyme activity in colocalized with surviving Purkinje cells. These results suggest strongly that the expression of 5'-nucleotidase activity by Bergmann glia is under the inductive influence of their associated Purkinje cells.
小脑皮质的分子层含有高水平的5'-核苷酸酶（EC 3.1.3.5），主要定位于伯格曼胶质细胞。在本研究中，已采用组织化学方法来检测两种不同突变株小鼠中小脑5'-核苷酸酶的分布，这两种突变株小鼠的浦肯野细胞被选择性消除。在纯合的“浦肯野细胞变性”（pcd）和“神经”（nr）小鼠中，分子层5'-核苷酸酶大大减少，残留的酶活性与存活的浦肯野细胞共定位。这些结果强烈表明，伯格曼胶质细胞5'-核苷酸酶活性的表达受到其相关浦肯野细胞的诱导影响。
