Moore Frederick A, Moore Ernest E, Billiar Timothy R, Vodovotz Yoram, Banerjee Anirban, Moldawer Lyle L
From the Acute Care Surgery division (F.A.M., L.L.M.), University of Florida, Gainesville, Florida; Department of Surgery (E.E.M., A.B.), Denver Health, University of Colorado, Denver, Colorado; and Department of Surgery (T.R.B., Y.V.), University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
J Trauma Acute Care Surg. 2017 Sep;83(3):520-531. doi: 10.1097/TA.0000000000001587.
The history of the National Institute of General Medical Sciences (NIGMS) Research Centers in Peri-operative Sciences (RCIPS) is the history of clinical, translational, and basic science research into the etiology and treatment of posttraumatic multiple organ failure (MOF). Born out of the activism of trauma and burn surgeons after the Viet Nam War, the P50 trauma research centers have been a nidus of research advances in the field and the training of future academic physician-scientists in the fields of trauma, burns, sepsis, and critical illness. For over 40 years, research conducted under the aegis of this funding program has led to numerous contributions at both the bedside and at the bench. In fact, it has been this requirement for team science with a clinician-scientist working closely with basic scientists from multiple disciplines that has led the RCIPS to its unrivaled success in the field. This review will briefly highlight some of the major accomplishments of the RCIPS program since its inception, how they have both led and evolved as the field moved steadily forward, and how they are responsible for much of our current understanding of the etiology and pathology of MOF. This review is not intended to be all encompassing nor a historical reference. Rather, it serves as recognition to the foresight and support of many past and present individuals at the NIGMS and at academic institutions who have understood the cost of critical illness and MOF to the individual and to society.
美国国立综合医学科学研究所围手术期科学研究中心（RCIPS）的历史，就是针对创伤后多器官功能衰竭（MOF）的病因及治疗开展临床、转化和基础科学研究的历史。P50创伤研究中心源自越战之后创伤和烧伤外科医生的积极行动，一直是该领域研究进展的核心以及未来创伤、烧伤、脓毒症和危重病领域学术医师科学家的培训基地。40多年来，在这一资助项目支持下开展的研究在临床和实验室都取得了众多成果。事实上，正是这种要求临床科学家与多学科基础科学家紧密合作的团队科学模式，使得RCIPS在该领域取得了无与伦比的成功。本综述将简要重点介绍RCIPS项目自成立以来的一些主要成就，它们如何随着该领域稳步发展而引领并演变，以及它们如何使我们目前对MOF的病因和病理有了诸多认识。本综述并非面面俱到，也不是历史参考资料。相反，它是对国立综合医学科学研究所及学术机构许多过去和现在的人士的远见卓识和支持的认可，他们深知危重病和MOF对个人及社会造成的代价。
