Department of Obstetrics and Gynecology, Cairo University, Cairo, Egypt.
Gynecol Endocrinol. 2012 Jul;28(7):570-2. doi: 10.3109/09513590.2011.593663. Epub 2012 Jun 1.
Our aim was to determine whether the level of plasma total ghrelin varies with the menopause stage (pre-, peri-, and postmenopause).
Women were divided in three groups: premenopausal, perimenopausal and postmenopausal. All participants had bone mineral densitometry and blood assay of plasma ghrelin, estradiol E2. Correlation between plasma ghrelin levels, their reproductive status and BMD was done.
The mean plasma level of ghrelin was significantly decreased in the perimenopausal and postmenopausal groups in comparison to the premenopausal group. A significant positive correlation was found between ghrelin and each of E₂ and BMD (at one or more of the three sites assessed) in all subjects, as well as, in peri- and postmenopausal women, whereas a significant negative correlation was found between ghrelin and FSH.
It may be assumed that ghrelin can affect BMD. Whether ghrelin and estrogen work independent or through convergent mechanisms needs further studies.
本研究旨在探讨血浆总 ghrelin 水平是否随绝经阶段（绝经前、围绝经期和绝经后）而变化。
将女性分为三组：绝经前、围绝经期和绝经后。所有参与者均接受骨密度和血浆 ghrelin、雌二醇 E2 检测。分析了血浆 ghrelin 水平与生殖状态和 BMD 的相关性。
与绝经前组相比，围绝经期和绝经后组的血浆 ghrelin 水平显著降低。在所有受试者以及围绝经期和绝经后妇女中，ghrelin 与 E₂和 BMD（在三个评估部位中的一个或多个部位）呈显著正相关，而与 FSH 呈显著负相关。
ghrelin 可能影响 BMD。ghrelin 和雌激素是通过独立机制还是通过趋同机制发挥作用，需要进一步研究。
