Roque Juliana Rejane da Silva, Machado Rodrigo Strehl, Rodrigues Douglas, Rech Patrícia, Kawakami Elisabete
MD, MSc. Postgraduate Student, Discipline of Pediatric Gastroenterology, Department of Pediatrics, Escola Paulista de Medicina - Universidade Federal de São Paulo (EPM-Unifesp), São Paulo (SP), Brazil.
MD, PhD. Clinical Instructor, Discipline of Pediatric Gastroenterology, Department of Pediatrics, Escola Paulista de Medicina - Universidade Federal de São Paulo (EPM-Unifesp), São Paulo (SP), Brazil.
Sao Paulo Med J. 2017 Mar-Apr;135(2):140-145. doi: 10.1590/1516-3180.2016.0114091216.
: The prevalence of Helicobacter pylori infection is unevenly distributed among different populations. The aim here was to evaluate the factors associated with Helicobacter pylori infection among children up to five years of age living in a high-risk community.
: Cross-sectional study in an indigenous community of Guarani Mbya ethnicity, Tekoa Ytu and Tekoa Pyau villages, Jaraguá district, city of São Paulo (SP), Brazil.
: 74 children aged 0.4 to 4.9 years (mean 2.9 ± 1.3 years; median 3.1), and 145 family members (86 siblings, 43 mothers and 16 fathers) were evaluated for Helicobacter pylori infection using the validated 13C-urea breath test. Clinical and demographic data were collected.
: The prevalence was 8.3% among children aged 1-2 years and reached 64.3% among those aged 4-5 years (P = 0.018; overall 31.1%). The prevalence was 76.7% among siblings and 89.8% among parents. There was a negative association with previous use of antibiotics in multivariate analysis adjusted for age (odds ratio, OR: 0.07; 95% confidence interval, CI: 0.01 to 0.66; P = 0.02). The prevalence was higher among males (OR: 1.55), and was associated with maternal infection (OR: 1.81), infection of both parents (OR: 1.5), vomiting (OR: 1.28), intestinal parasitosis (OR: 2.25), previous hospitalization (OR: 0.69) and breastfeeding (OR: 1.87).
: The prevalence was high among subjects older than three years of age, thus suggesting that the incidence of infection was higher over the first three years of life. Previous use of antibiotics was inversely associated with current Helicobacter pylori infection.
幽门螺杆菌感染率在不同人群中分布不均。本研究旨在评估生活在高危社区的5岁以下儿童幽门螺杆菌感染的相关因素。
在巴西圣保罗市（SP）雅拉瓜区特科阿伊图和特科阿皮奥村的瓜拉尼姆比亚族土著社区进行的横断面研究。
使用经过验证的13C尿素呼气试验对74名年龄在0.4至4.9岁（平均2.9±1.3岁；中位数3.1岁）的儿童以及145名家庭成员（86名兄弟姐妹、43名母亲和16名父亲）进行幽门螺杆菌感染评估。收集临床和人口统计学数据。
1 - 2岁儿童的感染率为8.3%，4 - 5岁儿童的感染率达到64.3%（P = 0.018；总体感染率为31.1%）。兄弟姐妹中的感染率为76.7%，父母中的感染率为89.8%。在按年龄调整的多变量分析中，既往使用抗生素与感染呈负相关（比值比，OR：0.07；95%置信区间，CI：0.01至0.66；P = 0.02）。男性感染率较高（OR：1.55），且与母亲感染（OR：1.81）、父母双方感染（OR：1.5）、呕吐（OR：1.28）、肠道寄生虫病（OR：2.25）、既往住院（OR：0.69）和母乳喂养（OR：1.87）有关。
3岁以上人群的感染率较高，这表明在生命的前三年感染发生率较高。既往使用抗生素与当前幽门螺杆菌感染呈负相关。
