Clinical Research Unity - Department of Internal Medicine - University Hospital Walter Cantídio - Federal University of Ceará, Fortaleza, Ceará, Brazil.
Helicobacter. 2010 Dec;15(6):491-6. doi: 10.1111/j.1523-5378.2010.00791.x.
To further evaluate intrafamilial transmission of H. pylori infection during childhood, we investigated the prevalence of H. pylori in family members from a poor H. pylori high-prevalence urban community in the Northeast of Brazil.
H. pylori infection was investigated in 570 members of 128 households, by (13) C-urea breath test in children and by ELISA in mothers and other adult relatives.
The overall prevalence of H. pylori infection (376/570) increased with age (p < .001) and ranged from 28.9%, in children aged 6 months to 5 years, to 82% in adults over 40 years. An H. pylori positive mother and the number of infected siblings are independent risk factors for childhood H. pylori infection (OR = 2.2, 95% CI = 1.0-4.6 and OR = 4.3, 95% CI = 2.3-8.1, respectively) The number of siblings, number of younger siblings, and number of infected younger siblings were also associated with the infection in the univariate analysis. The number of infected younger siblings remained independently associated with the infection (p = .000), even after controlling for all the above cited variables, in addition to the H. pylori status of siblings and mothers, age, number of people per room, and number of children in the household.
The transmission of H. pylori occurs from infected mothers to their offspring and among siblings, notably from younger siblings to the older ones.
为了进一步评估儿童时期幽门螺杆菌（H. pylori）感染的家族内传播情况，我们调查了来自巴西东北部一个高 H. pylori 感染率的贫困城市社区的家庭成员中 H. pylori 的流行情况。
通过（13）C-尿素呼气试验对 128 户家庭的 570 名成员中的儿童进行 H. pylori 感染调查，对母亲和其他成年亲属进行 ELISA 检测。
H. pylori 感染的总患病率（376/570）随年龄增长而增加（p<.001），范围从 6 个月至 5 岁儿童的 28.9%到 40 岁以上成年人的 82%。H. pylori 阳性母亲和感染的兄弟姐妹数量是儿童 H. pylori 感染的独立危险因素（OR=2.2，95%CI=1.0-4.6 和 OR=4.3，95%CI=2.3-8.1）。在单因素分析中，兄弟姐妹数量、年幼兄弟姐妹数量和感染的年幼兄弟姐妹数量也与感染有关。即使在控制了上述所有变量以及兄弟姐妹和母亲的 H. pylori 状态、年龄、人均房间数和家庭中的儿童人数后，感染的年幼兄弟姐妹数量仍与感染相关（p=.000）。
H. pylori 从感染的母亲传播给子女，以及在兄弟姐妹之间传播，特别是从年幼的兄弟姐妹传播给年长的兄弟姐妹。
