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异维A酸对痤疮患者嗅觉功能的影响。

Effects of isotretinoin on the olfactory function in patients with acne.

作者信息

Kartal Demet, Yaşar Mehmet, Kartal Levent, Özcan Ibrahim, Borlu Murat

机构信息

Department of Dermatology and Venereology - Erciyes University Faculty of Medicine - Kayseri, Turkey.

Department of Otorhinolaryngology - Kayseri Education and Research Hospital - Kayseri, Turkey.

出版信息

An Bras Dermatol. 2017 Mar-Apr;92(2):191-195. doi: 10.1590/abd1806-4841.20175483.

DOI:10.1590/abd1806-4841.20175483
PMID:28538877
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5429103/
Abstract

BACKGROUND

: Isotretinoin is a synthetic analog of vitamin A. Recent studies support a role for retinoic acid in the recovery of olfactory function following injury in mice.

OBJECTIVE

: This study aimed at determining the effect of isotretinoin on olfactory function in patients who have acne and are otherwise healthy.

METHODS

: Forty-five patients (aged 25-40 years) with acne were included in the study. All patients underwent a rhinological examination. Olfactory function was assessed by the Sniffin' Sticks Test. The test was assessed at baseline and in the third month of isotretinoin treatment.

RESULTS

: Isotretinoin improved the performance of patients in the olfactory test. The SST score increased from 8.7±1.09 to 9.5±1.19 (p<0.001), prevalence of hyposmia decreased from 40% to 24% and normosmia increased from 60% to 75% (p=0.059). The percentage of patients whose olfactory function was categorized as "good" increased from 6% to 21.3%. This increase was statistically significant (p<0.05).

STUDY LIMITATIONS

: Absence of a control group is one of the limitations of this study. Also, we did not evaluate patients with smell test after stopping isotretinoin treatment.

CONCLUSION

: We examined the effect of systemic isotretinoin on olfactory function. It can be concluded from the present investigation that isotretinoin therapy improves the sense of smell.

摘要

背景

异维A酸是维生素A的合成类似物。最近的研究支持维甲酸在小鼠嗅觉功能损伤后恢复中的作用。

目的

本研究旨在确定异维A酸对患有痤疮且身体健康的患者嗅觉功能的影响。

方法

45名年龄在25至40岁之间的痤疮患者纳入本研究。所有患者均接受了鼻科检查。嗅觉功能通过嗅棒测试进行评估。该测试在基线时以及异维A酸治疗的第三个月进行评估。

结果

异维A酸改善了患者在嗅觉测试中的表现。嗅棒测试（SST）评分从8.7±1.09提高到9.5±1.19（p<0.001），嗅觉减退的患病率从40%降至24%，嗅觉正常的比例从60%增至75%（p=0.059）。嗅觉功能被归类为“良好”的患者比例从6%增至21.3%。这一增加具有统计学意义（p<0.05）。

研究局限性

缺乏对照组是本研究的局限性之一。此外，我们没有在停止异维A酸治疗后对患者进行嗅觉测试评估。

结论

我们研究了全身性异维A酸对嗅觉功能的影响。从本调查可以得出结论，异维A酸治疗可改善嗅觉。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f255/5429103/7639e940feae/abd-92-02-0191-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f255/5429103/44484ae9c4fb/abd-92-02-0191-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f255/5429103/7fd58274d97e/abd-92-02-0191-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f255/5429103/7cf867c9d1a4/abd-92-02-0191-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f255/5429103/a54490e36337/abd-92-02-0191-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f255/5429103/5fd76c894b92/abd-92-02-0191-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f255/5429103/7639e940feae/abd-92-02-0191-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f255/5429103/44484ae9c4fb/abd-92-02-0191-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f255/5429103/7fd58274d97e/abd-92-02-0191-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f255/5429103/7cf867c9d1a4/abd-92-02-0191-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f255/5429103/a54490e36337/abd-92-02-0191-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f255/5429103/5fd76c894b92/abd-92-02-0191-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f255/5429103/7639e940feae/abd-92-02-0191-g06.jpg

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本文引用的文献

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The sweet smell of ... implicit helping: effects of pleasant ambient fragrance on spontaneous help in shopping malls.香甜的气味……隐含的帮助：商场中宜人环境香味对自发性帮助的影响。
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Olfactory function in patients with postinfectious and posttraumatic smell disorders before and after treatment with vitamin A: a double-blind, placebo-controlled, randomized clinical trial.
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How are Acne Vulgaris Patients Using Oral Isotretinoin Affected by Covid-19?寻常痤疮患者使用口服异维A酸受新冠病毒病影响情况如何？
Dermatol Pract Concept. 2022 Jul 1;12(3):e2022146. doi: 10.5826/dpc.1203a146. eCollection 2022 Jul.
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International consensus statement on allergy and rhinology: Olfaction.国际过敏与鼻科学学会共识声明：嗅觉。
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