Sokolova I B, Sergeev I V, Fedotova O R, Melnikova N N, Dvoretsky D P
I.V.Pavlov Institute of Physiology, RAS, Saint-Petersburg, Russian Federation;
Research Institute of Experimental Medicine, RAMS, Saint-Petersburg, Russian Federation.
Adv Gerontol. 2016;29(4):567-572.
We studied the density of the microvascular network in the pia mater, the tissue perfusion and saturation of the oxygen of sensorimotor cortex of hypertensive rats of different ages. Our investigations shown that the microvascular density in the pia mater was not only decreased, but also was increased. The perfusion of sensorimotor cortex was reduced and tissue saturation was enlarged. By the age of 12 months orienting-exploratory rats behavior became worse significantly in all major indicators of the test «open field».
我们研究了不同年龄高血压大鼠软脑膜微血管网络的密度、感觉运动皮层的组织灌注及氧饱和度。我们的研究表明，软脑膜中的微血管密度不仅降低，而且还增加了。感觉运动皮层的灌注减少，组织饱和度增大。到12个月大时，在“旷场”试验的所有主要指标中，定向探索大鼠的行为明显变差。
